Gaining Insights Into Multiple Sclerosis Lesion Characteristics from Brain Tissue Microstructure Information: A Multi-Compartment T2 Relaxometry Approach
Résumé
Clinical trends and pathogenetic ways of onset and progression of Multiple Sclerosis (MS) in patients suggest that MS is a highly heterogeneous disease. MS is predominantly a White Matter (WM) disease, which is mainly composed of myelinated axons and neuroglia type cells. Demyelination and axonal loss characterize the condition of MS in a patient. However, they follow varying trends in patients. In this work, we propose a method in which T2 relaxometry data is used to obtain a quantitative brain tissue microstructure information. This information is then studied to check its corroborations with pathogenetic understanding of MS in literature.
Domaines
Psychiatrie et santé mentaleOrigine | Fichiers produits par l'(les) auteur(s) |
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