Article Dans Une Revue Molecular Pharmaceutics Année : 2026

Microbubbles for Acoustically Mediated Drug Delivery to the Inner Ear

Résumé

The blood-labyrinth barrier (BLB) is a seleccve endothelial barrier that maintains the homeostasis of the inner ear and protects it against toxic molecules and pathogens. This highly seleccve barrier represents a significant challenge for the delivery of therapeucc agents to the inner ear. To overcome this issue, various drug delivery methods have been developed. Among these modalices, microbubble-assisted ultrasound is an innovacve and promising method for the non-invasive, targeted and efficient delivery of therapeucc agents through the round window membrane. The safety and the efficacy of this physical modality is strongly dependent of physiological properces of the targeted cssue, the pharmacological properces of the therapeucc molecules, the ultrasound parameters but also microbubble-related properces. The present review focuses on the current state of MB formulacons and their use for the acousccally mediated inner ear drug delivery.

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inserm-05492017 , version 1 (03-02-2026)

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Charlotte Jeanneau, Fabrice Micaletti, Damien Fouan, Valérie Schubnel, Cédric Chauvierre, et al.. Microbubbles for Acoustically Mediated Drug Delivery to the Inner Ear. Molecular Pharmaceutics, 2026, 23 (3), pp.1419-1433. ⟨10.1021/acs.molpharmaceut.5c01397⟩. ⟨inserm-05492017⟩
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