An Update on Tamoxifen and the Chemo-Preventive Potential of Vitamin E in Breast Cancer Management - Inserm - Institut national de la santé et de la recherche médicale Accéder directement au contenu
Article Dans Une Revue Journal of Personalized Medicine Année : 2023

An Update on Tamoxifen and the Chemo-Preventive Potential of Vitamin E in Breast Cancer Management

Mourad a M Aboul-Soud

Résumé

Breast cancer (BC) is the most common female cancer in terms of incidence and mortality worldwide. Tamoxifen (Nolvadex) is a widely prescribed, oral anti-estrogen drug for the hormonal treatment of estrogen-receptor-positive BC, which represents 70% of all BC subtypes. This review assesses the current knowledge on the molecular pharmacology of tamoxifen in terms of its anticancer and chemo-preventive actions. Due to the importance of vitamin E compounds, which are widely taken as a supplementary dietary component, the review focuses only on the potential importance of vitamin E in BC chemo-prevention. The chemo-preventive and onco-protective effects of tamoxifen combined with the potential effects of vitamin E can alter the anticancer actions of tamoxifen. Therefore, methods involving an individually designed, nutritional intervention for patients with BC warrant further consideration. These data are of great importance for tamoxifen chemo-prevention strategies in future epidemiological studies.
Fichier principal
Vignette du fichier
jpm-13-00754 (1).pdf (1.52 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Licence : CC BY - Paternité

Dates et versions

inserm-04165318 , version 1 (18-07-2023)

Identifiants

Citer

Farid Khallouki, Lhoussain Hajji, Somayya Saber, Toufik Bouddine, Mouad Edderkaoui, et al.. An Update on Tamoxifen and the Chemo-Preventive Potential of Vitamin E in Breast Cancer Management. Journal of Personalized Medicine, 2023, 13 (5), pp.754. ⟨10.3390/jpm13050754⟩. ⟨inserm-04165318⟩
11 Consultations
7 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More