Alternative splicing of hepatitis B virus: A novel virus/host interaction altering liver immunity - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles Journal of Hepatology Year : 2017

Alternative splicing of hepatitis B virus: A novel virus/host interaction altering liver immunity

Yassmina Mandouri
  • Function : Author
Bouchra Lekbaby
  • Function : Author
Hualin Wang
  • Function : Author
Aurélie Schnuriger
  • Function : Author
Francois Redelsperger
  • Function : Author
Chiara Ida Guerrera
  • Function : Author
Marine Lefevre
  • Function : Author
Veronique Fauveau
  • Function : Author
James Ahodantin
  • Function : Author
Ivan Quetier
  • Function : Author
Cerina Chhuon
Samir Gourari
  • Function : Author
Alexandre Boissonnas
  • Function : Author
Upkar Gill
  • Function : Author
Patrick Kennedy
  • Function : Author
Nabil Debzi
  • Function : Author
Delphine Sitterlin
  • Function : Author
Mala K Maini
  • Function : Author
Dina Kremsdorf
  • Function : Author
Patrick Soussan

Abstract

Background & aims-Hepatitis B virus (HBV) RNA can undergo alternative splicing but the relevance of this post-transcriptional regulation remains elusive. Here, the mechanism of HBV alternative splicing regulation and its impact on liver pathogenesis were investigated. Methods-HBV RNA-interacting proteins were identified by RNA pull-down combined to mass spectrometry analysis. HBV splicing regulation was investigated in chemically and surgically induced liver damage in whole HBV genome transgenic mice and in hepatoma cells. Viral and
Fichier principal
Vignette du fichier
emss-82160.pdf (3.12 Mo) Télécharger le fichier
Origin Files produced by the author(s)

Dates and versions

inserm-03990705 , version 1 (15-02-2023)

Identifiers

Cite

Marion Duriez, Yassmina Mandouri, Bouchra Lekbaby, Hualin Wang, Aurélie Schnuriger, et al.. Alternative splicing of hepatitis B virus: A novel virus/host interaction altering liver immunity. Journal of Hepatology, 2017, 67 (4), pp.687-699. ⟨10.1016/j.jhep.2017.05.025⟩. ⟨inserm-03990705⟩
15 View
21 Download

Altmetric

Share

Gmail Mastodon Facebook X LinkedIn More