Article Dans Une Revue Journal of Hepatology Année : 2017

Alternative splicing of hepatitis B virus: A novel virus/host interaction altering liver immunity

Samir Gourari
  • Fonction : Auteur
Upkar Gill
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Patrick Kennedy
  • Fonction : Auteur
Nabil Debzi
  • Fonction : Auteur
Mala K Maini
  • Fonction : Auteur

Résumé

Background & aims-Hepatitis B virus (HBV) RNA can undergo alternative splicing but the relevance of this post-transcriptional regulation remains elusive. Here, the mechanism of HBV alternative splicing regulation and its impact on liver pathogenesis were investigated. Methods-HBV RNA-interacting proteins were identified by RNA pull-down combined to mass spectrometry analysis. HBV splicing regulation was investigated in chemically and surgically induced liver damage in whole HBV genome transgenic mice and in hepatoma cells. Viral and

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Dates et versions

inserm-03990705 , version 1 (15-02-2023)

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Marion Duriez, Yassmina Mandouri, Bouchra Lekbaby, Hualin Wang, Aurélie Schnuriger, et al.. Alternative splicing of hepatitis B virus: A novel virus/host interaction altering liver immunity. Journal of Hepatology, 2017, 67 (4), pp.687-699. ⟨10.1016/j.jhep.2017.05.025⟩. ⟨inserm-03990705⟩
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