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Journal Articles Journal of Allergy and Clinical Immunology Year : 2017

Polyfunctionality of bona fide resident lung CD69 + natural killer cells


with the correlation of total IL-18 and macrophage activation syndrome (MAS)-prone conditions, they found elevated free IL-18 specifically in patients with Still's disease, and also observed a higher IL-18/IL-18BP affinity than previously described. Further investigation is warranted to better understand discrepancies between calculated and measured free IL-18, and appropriate caution should be taken in the interpretation of calculated free IL-18 until the aforementioned assumptions have been addressed. This report provides the first clinical clues that the association between free IL-18 and MAS is no mere epiphenomenon. Specifically, the magnitude and chronicity of elevated IL-18 in NLRC4-related MAS (and in most systemic juvenile idiopathic arthritis 5) might suggest a ''priming'' effect for exuberant MAS-like responses. However, this patient's rapid improvement also implicates a role for IL-18 in propagating inflammation. In addition, the patient's enterocolitis was associated with substantially more free IL-18 in stool than in serum, suggesting less buffering by IL-18BP at mucosal surfaces. Overall, the important work initiated nearly 2 decades ago in describing the endogenous regulation of IL-18 continues to undergo scientific, and now clinical, refinement as we better understand the homeostatic and pathogenic functions of this cytokine.
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inserm-03990662 , version 1 (15-02-2023)



Baptiste Hervier, Isabelle Cremer, Vincent Vieillard. Polyfunctionality of bona fide resident lung CD69 + natural killer cells. Journal of Allergy and Clinical Immunology, 2017, 140 (1), pp.317-318. ⟨10.1016/j.jaci.2017.02.042⟩. ⟨inserm-03990662⟩
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