%0 Journal Article %T Polyfunctionality of bona fide resident lung CD69 + natural killer cells %+ Centre d'Immunologie et des Maladies Infectieuses (CIMI) %+ CHU Pitié-Salpêtrière [AP-HP] %+ Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)) %A Hervier, Baptiste %A Cremer, Isabelle %A Vieillard, Vincent %< avec comité de lecture %@ 0091-6749 %J Journal of Allergy and Clinical Immunology %I Elsevier %V 140 %N 1 %P 317-318 %8 2017-07 %D 2017 %R 10.1016/j.jaci.2017.02.042 %M 28528926 %Z Life Sciences [q-bio]Journal articles %X with the correlation of total IL-18 and macrophage activation syndrome (MAS)-prone conditions, they found elevated free IL-18 specifically in patients with Still's disease, and also observed a higher IL-18/IL-18BP affinity than previously described. Further investigation is warranted to better understand discrepancies between calculated and measured free IL-18, and appropriate caution should be taken in the interpretation of calculated free IL-18 until the aforementioned assumptions have been addressed. This report provides the first clinical clues that the association between free IL-18 and MAS is no mere epiphenomenon. Specifically, the magnitude and chronicity of elevated IL-18 in NLRC4-related MAS (and in most systemic juvenile idiopathic arthritis 5) might suggest a ''priming'' effect for exuberant MAS-like responses. However, this patient's rapid improvement also implicates a role for IL-18 in propagating inflammation. In addition, the patient's enterocolitis was associated with substantially more free IL-18 in stool than in serum, suggesting less buffering by IL-18BP at mucosal surfaces. Overall, the important work initiated nearly 2 decades ago in describing the endogenous regulation of IL-18 continues to undergo scientific, and now clinical, refinement as we better understand the homeostatic and pathogenic functions of this cytokine. %G English %2 https://inserm.hal.science/inserm-03990662/document %2 https://inserm.hal.science/inserm-03990662/file/1-s2.0-S0091674917306711-main.pdf %L inserm-03990662 %U https://inserm.hal.science/inserm-03990662 %~ INSERM %~ EPHE %~ CNRS %~ APHP %~ CORDELIERS %~ CIMI %~ PSL %~ SORBONNE-UNIVERSITE %~ SU-INF-2018 %~ SU-MEDECINE %~ SU-SCIENCES %~ TEST-DEV %~ SU-MED %~ UP-SANTE %~ EPHE-PSL %~ SU-TI %~ ALLIANCE-SU