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Journal Articles Viruses Year : 2017

Canonical and Non-Canonical Autophagy in HIV-1 Replication Cycle

Abstract

Autophagy is a lysosomal-dependent degradative process essential for maintaining cellular homeostasis, and is a key player in innate and adaptive immune responses to intracellular pathogens such as human immunodeficiency virus type 1 (HIV-1). In HIV-1 target cells, autophagy mechanisms can (i) selectively direct viral proteins and viruses for degradation; (ii) participate in the processing and presentation of viral-derived antigens through major histocompatibility complexes; and (iii) contribute to interferon production in response to HIV-1 infection. As a consequence, HIV-1 has evolved different strategies to finely regulate the autophagy pathway to favor its replication and dissemination. HIV-1 notably encodes accessory genes encoding Tat, Nef and Vpu proteins, which are able to perturb and hijack canonical and non-canonical autophagy mechanisms. This review outlines the current knowledge on the complex interplay between autophagy and HIV-1 replication cycle, providing an overview of the autophagy-mediated molecular processes deployed both by infected cells to combat the virus and by HIV-1 to evade antiviral response.
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inserm-03981639 , version 1 (09-02-2023)

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Olivier Leymarie, Leslie Lepont, Clarisse Berlioz-Torrent. Canonical and Non-Canonical Autophagy in HIV-1 Replication Cycle. Viruses, 2017, 9 (10), pp.270. ⟨10.3390/v9100270⟩. ⟨inserm-03981639⟩
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