Glial Purinergic Signaling in Neurodegeneration - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles Frontiers in Neurology Year : 2021

Glial Purinergic Signaling in Neurodegeneration

Abstract

Purinergic signaling regulates neuronal and glial cell functions in the healthy CNS. In neurodegenerative diseases, purinergic signaling becomes dysregulated and can affect disease-associated phenotypes of glial cells. In this review, we discuss how cell-specific expression patterns of purinergic signaling components change in neurodegeneration and how dysregulated glial purinergic signaling and crosstalk may contribute to disease pathophysiology, thus bearing promising potential for the development of new therapeutical options for neurodegenerative diseases.
Fichier principal
Vignette du fichier
fneur-12-654850.pdf (1.71 Mo) Télécharger le fichier
Origin : Publisher files allowed on an open archive

Dates and versions

inserm-03385134 , version 1 (19-10-2021)

Identifiers

Cite

Marie Pietrowski, Amr Ahmed Gabr, Stanislav Kozlov, David Blum, Annett Halle, et al.. Glial Purinergic Signaling in Neurodegeneration. Frontiers in Neurology, 2021, 12, pp.654850. ⟨10.3389/fneur.2021.654850⟩. ⟨inserm-03385134⟩
20 View
99 Download

Altmetric

Share

Gmail Facebook X LinkedIn More