Uncovering the Role of Glycogen in Brown Adipose Tissue - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles Pharmaceutical Research Year : 2021

Uncovering the Role of Glycogen in Brown Adipose Tissue


The presence of glycogen in the brown adipose tissue (BAT) has been described 60 years ago. However, the role of this energetic storage in brown adipocytes has been long time underestimated. We have recently shown that during brown adipocyte differentiation in the embryo, glycogen accumulates and is degraded by glycophagy, a dynamic essential for lipid droplets biogenesis. Recent studies have shown that the storage and degradation of triglycerides in BAT are not essential for the activation of BAT in response to cold exposure in adults, and that glycogen can compensate for their absence. In this review, we report the recent advances related to the importance of glycogen in brown adipocytes.
Fichier principal
Vignette du fichier
Pharmaceutical Research_Jan2021.pdf (363.81 Ko) Télécharger le fichier
Origin : Files produced by the author(s)

Dates and versions

inserm-03121019 , version 1 (26-01-2021)



Alicia Mayeuf-Louchart. Uncovering the Role of Glycogen in Brown Adipose Tissue. Pharmaceutical Research, 2021, 38, pp.9-14. ⟨10.1007/s11095-020-02979-6⟩. ⟨inserm-03121019⟩
191 View
385 Download



Gmail Facebook X LinkedIn More