A germline oncogenic MITF mutation and tumor susceptibility - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles European Journal of Cell Biology Year : 2014

A germline oncogenic MITF mutation and tumor susceptibility


MITF (Microphthalmia-associated transcription factor) is a lineage specific transcription factor that plays a critical role in melanocyte homeostasis and whose deregulation has been shown to contribute to melanoma disease. A germline mutation in MITF, impairing SUMOylation and predisposing to cutaneous malignant melanoma, was recently identified. Interestingly, an association of the MITF mutation with coexisting melanoma and renal cell carcinoma was also shown. Collectively, these data suggest that MITF has an important oncogenic function in tumorigenesis of multiple tissues/melanocytes and kidney cells.



Fichier principal
Vignette du fichier
Bressac-de Paillerets EJC.pdf (380.02 Ko) Télécharger le fichier
Origin : Files produced by the author(s)

Dates and versions

inserm-02530572 , version 1 (20-04-2020)



Brigitte Bressac-De Paillerets, Fabienne Lesueur, Corine Bertolotto. A germline oncogenic MITF mutation and tumor susceptibility. European Journal of Cell Biology, 2014, 93 (1-2), pp.71-75. ⟨10.1016/j.ejcb.2013.10.002⟩. ⟨inserm-02530572⟩
151 View
397 Download



Gmail Facebook X LinkedIn More