ADAMTS proteoglycanases in the physiological and pathological central nervous system. - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles Journal of Neuroinflammation Year : 2013

ADAMTS proteoglycanases in the physiological and pathological central nervous system.

Abstract

: ADAMTS-1, -4, -5 and -9 belong to 'a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)' family and more precisely to the proteoglycanases subgroup based on their common ability to degrade chondroitin sulfate proteoglycans. They have been extensively investigated for their involvement in inflammation-induced osteoarthritis, and a growing body of evidence indicates that they may be of key importance in the physiological and pathological central nervous system (CNS). In this review, we discuss the deregulated expression of ADAMTS proteoglycanases during acute CNS injuries, such as stroke and spinal cord injury. Then, we provide new insights on ADAMTS proteoglycanases mediating synaptic plasticity, neurorepair, angiogenesis and inflammation mechanisms. Altogether, this review allows us to propose that ADAMTS proteoglycanases may be original therapeutic targets for CNS injuries.
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Dates and versions

inserm-00903345 , version 1 (12-11-2013)

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Sighild Lemarchant, Mathilde Pruvost, Joan Montaner, Evelyne Emery, Denis Vivien, et al.. ADAMTS proteoglycanases in the physiological and pathological central nervous system.. Journal of Neuroinflammation, 2013, 10 (1), pp.133. ⟨10.1186/1742-2094-10-133⟩. ⟨inserm-00903345⟩
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