%0 Journal Article %T ADAMTS proteoglycanases in the physiological and pathological central nervous system. %+ Department of Neurobiology %+ Sérine protéases et physiopathologie de l'unité neurovasculaire %+ Neurovascular Research Laboratory %+ Service de Neurochirurgie [CHU Caen] %+ Department of Oncology %A Lemarchant, Sighild %A Pruvost, Mathilde %A Montaner, Joan %A Emery, Evelyne %A Vivien, Denis %A Kanninen, Katja %A Koistinaho, Jari %Z This work was supported by the University of Eastern Finland and the ERANET-Neuron research program 'ProteA: Proteases before, during and after stroke', 2012-2015 %< avec comité de lecture %@ 1742-2094 %J Journal of Neuroinflammation %I BioMed Central %V 10 %N 1 %P 133 %8 2013-10-31 %D 2013 %R 10.1186/1742-2094-10-133 %M 24176075 %K A disintegrin and metalloproteinase with thrombospondin motifs %K Proteoglycanases %K Stroke %K Spinal cord injury %K Chondroitin sulfate proteoglycan %K Synaptic plasticity %K Inflammation %K Angiogenesis %K Neurorepair %Z Life Sciences [q-bio]/Immunology %Z Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/NeurobiologyJournal articles %X : ADAMTS-1, -4, -5 and -9 belong to 'a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)' family and more precisely to the proteoglycanases subgroup based on their common ability to degrade chondroitin sulfate proteoglycans. They have been extensively investigated for their involvement in inflammation-induced osteoarthritis, and a growing body of evidence indicates that they may be of key importance in the physiological and pathological central nervous system (CNS). In this review, we discuss the deregulated expression of ADAMTS proteoglycanases during acute CNS injuries, such as stroke and spinal cord injury. Then, we provide new insights on ADAMTS proteoglycanases mediating synaptic plasticity, neurorepair, angiogenesis and inflammation mechanisms. Altogether, this review allows us to propose that ADAMTS proteoglycanases may be original therapeutic targets for CNS injuries. %G English %2 https://inserm.hal.science/inserm-00903345/document %2 https://inserm.hal.science/inserm-00903345/file/1742-2094-10-133.pdf %L inserm-00903345 %U https://inserm.hal.science/inserm-00903345 %~ INSERM %~ COMUE-NORMANDIE %~ UNICAEN