Membrane microvesicles: a circulating source for fibrinolysis, new antithrombotic messengers. - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles Haematologica Year : 2013

Membrane microvesicles: a circulating source for fibrinolysis, new antithrombotic messengers.

Abstract

Thrombus lysis is the consequence of a restricted number of reactions localised on the surface of fibrin and cell membranes. A functional defect or an insufficient fibrinolytic response may result in thrombosis with severe or fatal clinical consequences. Despite this clinical exigency and a real progress in the knowledge of the different components of this system (plasminogen activators, inhibitors and receptors) including structure-function relationship unveiled by the crystal structure of plasminogen, the functional evaluation of fibrinolysis still remains a challenge in haemostasis. Interestingly, we recently discovered that circulating membrane microvesicles might be indicators of the fibrinolytic response to an inflammatory or prothrombotic process via their participation in a new mechanism of plasmin formation requiring a cross-talk between two different surfaces. We propose that the fibrinolytic activity conveyed by microvesicles could be the real source of fibrinolysis in circulating blood.
Fichier principal
Vignette du fichier
HAEMATOL-2013-088948v3-AngleI_s-Cano.pdf (57.06 Ko) Télécharger le fichier
Haematologica2013_98_e75.pdf (94.5 Ko) Télécharger le fichier
Origin : Publisher files allowed on an open archive
Origin : Publisher files allowed on an open archive

Dates and versions

inserm-00851463 , version 1 (14-08-2013)

Identifiers

Cite

Laurent Plawinski, Eduardo Anglés-Cano. Membrane microvesicles: a circulating source for fibrinolysis, new antithrombotic messengers.. Haematologica, 2013, 98 (7), pp.e75-6. ⟨10.3324/haematol.2013.088948⟩. ⟨inserm-00851463⟩
107 View
489 Download

Altmetric

Share

Gmail Facebook X LinkedIn More