%0 Journal Article %T Membrane microvesicles: a circulating source for fibrinolysis, new antithrombotic messengers. %+ Chimie et Biologie des Membranes et des Nanoobjets (CBMN) %+ Risque Thrombotique et Mécanismes de l'Hémostase (U765) %A Plawinski, Laurent %A Anglés-Cano, Eduardo %Z Inserm %< avec comité de lecture %@ 0390-6078 %J Haematologica %I Ferrata Storti Foundation %V 98 %N 7 %P e75-6 %8 2013-07 %D 2013 %R 10.3324/haematol.2013.088948 %M 23813650 %K Fibrinolysis %K Microvesicles %K Microparticles %K Thrombosis %K Plasmin %Z Life Sciences [q-bio]/Biochemistry, Molecular BiologyJournal articles %X Thrombus lysis is the consequence of a restricted number of reactions localised on the surface of fibrin and cell membranes. A functional defect or an insufficient fibrinolytic response may result in thrombosis with severe or fatal clinical consequences. Despite this clinical exigency and a real progress in the knowledge of the different components of this system (plasminogen activators, inhibitors and receptors) including structure-function relationship unveiled by the crystal structure of plasminogen, the functional evaluation of fibrinolysis still remains a challenge in haemostasis. Interestingly, we recently discovered that circulating membrane microvesicles might be indicators of the fibrinolytic response to an inflammatory or prothrombotic process via their participation in a new mechanism of plasmin formation requiring a cross-talk between two different surfaces. We propose that the fibrinolytic activity conveyed by microvesicles could be the real source of fibrinolysis in circulating blood. %G English %2 https://inserm.hal.science/inserm-00851463/document %2 https://inserm.hal.science/inserm-00851463/file/HAEMATOL-2013-088948v3-AngleI_s-Cano.pdf %2 https://inserm.hal.science/inserm-00851463/file/Haematologica2013_98_e75.pdf %L inserm-00851463 %U https://inserm.hal.science/inserm-00851463 %~ INSERM %~ IRD %~ UNIV-PARIS5 %~ ENSCP %~ CNRS %~ ENSC-PARIS %~ IFR71 %~ PARISTECH %~ INC-CNRS %~ PSL %~ UNIV-PARIS %~ ENSCP-PSL %~ TEST2-HALCNRS