Reconstitution of the entire hepatitis C virus life cycle in non-hepatic cells.
Abstract
Hepatitis C virus (HCV) is a human hepatotropic virus, yet the relevant host factors restricting HCV infection to hepatocytes are only partially understood. We demonstrate that exogenous expression of defined host factors reconstituted the entire HCV life cycle in human non-hepatic 293T cells. This study shows robust HCV entry, RNA replication, and production of infectious virus in human non-hepatic cells, and highlights key host factors required for liver tropism of HCV.
Domains
Hépatology and Gastroenterology
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Origin : Files produced by the author(s)
Origin : Files produced by the author(s)