Regulating TRAIL receptor-induced cell death at the membrane : a deadly discussion. - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles Recent Pat Anticancer Drug Discov Year : 2011

Regulating TRAIL receptor-induced cell death at the membrane : a deadly discussion.

Abstract

The use of TRAIL/APO2L and monoclonal antibodies targeting TRAIL receptors for cancer therapy holds great promise, due to their ability to restore cancer cell sensitivity to apoptosis in association with conventional chemotherapeutic drugs in a large variety of tumors. TRAIL-induced cell death is tightly regulated right from the membrane and at the DISC (Death-Inducing Signaling Complex) level. The following patent and literature review aims to present and highlight recent findings of the deadly discussion that determines tumor cell fate upon TRAIL engagement.
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Dates and versions

inserm-00609574 , version 1 (19-07-2011)

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Sarah Shirley, Alexandre Morizot, Olivier Micheau. Regulating TRAIL receptor-induced cell death at the membrane : a deadly discussion.: TRAIL - A deadly DISCussion. Recent Pat Anticancer Drug Discov, 2011, 6 (3), pp.311-23. ⟨10.2174/157489211796957757⟩. ⟨inserm-00609574⟩
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