Structure of full-length PPARgamma-RXRalpha: a snapshot of a functional complex? - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles Cell Metab Year : 2009

Structure of full-length PPARgamma-RXRalpha: a snapshot of a functional complex?

Abstract

The first crystal structure of a full-length nuclear receptor complex on DNA reveals an interdomain contact between the ligand- and DNA-binding domains of subunits and illuminates the role of the 5' extension of the binding site in polarity of positioning. These findings have possible functional implications.

Dates and versions

inserm-00357462 , version 1 (30-01-2009)

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Dino Moras. Structure of full-length PPARgamma-RXRalpha: a snapshot of a functional complex?. Cell Metab, 2009, 9 (1), pp.8-10. ⟨10.1016/j.cmet.2008.12.010⟩. ⟨inserm-00357462⟩
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