%0 Journal Article %T Structure of full-length PPARgamma-RXRalpha: a snapshot of a functional complex? %+ Institut de génétique et biologie moléculaire et cellulaire (IGBMC) %A Moras, Dino %< avec comité de lecture %J Cell Metab %V 9 %N 1 %P 8-10 %8 2009-01-07 %D 2009 %R 10.1016/j.cmet.2008.12.010 %M 19117542 %Z Life Sciences [q-bio]/Biochemistry, Molecular BiologyJournal articles %X The first crystal structure of a full-length nuclear receptor complex on DNA reveals an interdomain contact between the ligand- and DNA-binding domains of subunits and illuminates the role of the 5' extension of the binding site in polarity of positioning. These findings have possible functional implications. %G English %L inserm-00357462 %U https://inserm.hal.science/inserm-00357462 %~ INSERM %~ CNRS %~ UNIV-STRASBG1 %~ IGBMC %~ UNIV-STRASBG %~ SITE-ALSACE