Long-term follow-up of 111 patients with persistent polyclonal B-cell lymphocytosis with binucleated lymphocytes.
Abstract
Initially described in 1982, the persistent polyclonal B-cell lymphocytosis (PPBL) is characterized by a chronic, stable, persistent and polyclonal lymphocytosis, the presence of binucleated lymphocytes in the peripheral blood and a polyclonal increase in serum immunoglobulin-M (IgM). In this apparently benign entity, we showed that PPBL was associated with recurrent chromosomal abnormalities and a typical cytogenetic profile including isochromosome 3q, +i(3q), premature chromosome condensation (PCC), both abnormalities in the same patient or chromosomal instability. Despite clinical and polyclonal lymphocytosis stability, the long-term follow-up is not yet well established.We analyse and report here the long-term follow-up of 111 patients with typical PPBL.
Domains
Hematology
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Letter_Leuk_ver_definitive_.pdf (129.18 Ko)
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Origin : Files produced by the author(s)
Origin : Files produced by the author(s)