%0 Journal Article %T Long-term follow-up of 111 patients with persistent polyclonal B-cell lymphocytosis with binucleated lymphocytes. %+ Laboratoire d'Hématologie Biologique [CHU Caen] %+ Service d'Hématologie Biologique [CHRU Nancy] %+ Laboratoire de Cytogénétique - Pasteur-Cerba %+ Laboratoire d'Hématologie %+ Centre d'Investigations Cliniques 9504 %+ Biostatistique et épidemiologie clinique %+ CHU Pitié-Salpêtrière [AP-HP] %A Cornet, Edouard %A Lesesve, Jean François %A Mossafa, Hossein %A Sébahoun, Gérard %A Levy, Vincent %A Davi, Frédéric %A Troussard, Xavier %< avec comité de lecture %@ 0887-6924 %J Leukemia %I Springer Nature %V 23 %N 2 %P 419-22 %8 2009-02 %D 2009 %R 10.1038/leu.2008.208 %M 18668130 %Z Life Sciences [q-bio]/Human health and pathology/HematologyJournal articles %X Initially described in 1982, the persistent polyclonal B-cell lymphocytosis (PPBL) is characterized by a chronic, stable, persistent and polyclonal lymphocytosis, the presence of binucleated lymphocytes in the peripheral blood and a polyclonal increase in serum immunoglobulin-M (IgM). In this apparently benign entity, we showed that PPBL was associated with recurrent chromosomal abnormalities and a typical cytogenetic profile including isochromosome 3q, +i(3q), premature chromosome condensation (PCC), both abnormalities in the same patient or chromosomal instability. Despite clinical and polyclonal lymphocytosis stability, the long-term follow-up is not yet well established.We analyse and report here the long-term follow-up of 111 patients with typical PPBL. %G English %2 https://inserm.hal.science/inserm-00338136/document %2 https://inserm.hal.science/inserm-00338136/file/Letter_Leuk_ver_definitive_.pdf %2 https://inserm.hal.science/inserm-00338136/file/inserm-00338136_edited.pdf %L inserm-00338136 %U https://inserm.hal.science/inserm-00338136 %~ INSERM %~ UNIV-PARIS7 %~ APHP %~ COMUE-NORMANDIE %~ UNIV-LORRAINE %~ UNICAEN %~ SORBONNE-UNIVERSITE %~ SU-INF-2018 %~ SU-MEDECINE %~ SU-MED %~ UNIV-PARIS %~ SU-TI %~ ALLIANCE-SU