[Survivin, the starlet of the passenger protein complex. Check-up for its tenth anniversary.] - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles Médecine/Sciences Year : 2008

[Survivin, the starlet of the passenger protein complex. Check-up for its tenth anniversary.]

Abstract

Ten year after its discovery Survivin has gained a strategic place within the chromosomal passenger complex. Whereas INCENP, Borealin and Aurora B are fully immobile in the complex, Survivin is mobile on centromere. Its mobility is regulated both by phosphorylation and ubiquitination. Survivin is a dynamic messenger that senses the central spindle tension and participates to the control of the mitotic chekpoint. In this review, we have detailed the multiple mitotic activities of Survivin and discussed them in light of the recent reported cristallographic data.

Domains

Genetics
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Origin : Files produced by the author(s)
Origin : Files produced by the author(s)

Dates and versions

inserm-00336277 , version 1 (03-11-2008)

Identifiers

  • HAL Id : inserm-00336277 , version 1
  • PUBMED : 18950578

Cite

Marlène Delacour-Larose, Thi My Nhung Hoang, Annie Molla. [Survivin, the starlet of the passenger protein complex. Check-up for its tenth anniversary.]. Médecine/Sciences, 2008, 24 (10), pp.828-32. ⟨inserm-00336277⟩

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