Article Dans Une Revue npj Parkinson's Disease Année : 2024

Intracellular α-synuclein assemblies are sufficient to alter nanoscale diffusion in the striatal extracellular space

Résumé

α-synucleinopathies progression involves the spread of α-synuclein aggregates through the extracellular space (ECS). Single-particle tracking studies showed that α-synuclein-induced neurodegeneration increases ECS molecular diffusivity. To disentangle the consequences of neuronal loss versus α-synuclein-positive intracellular assemblies formation, we performed near-infrared single-particle tracking to characterise ECS rheology in the striatum of mouse models of α-synucleinopathies. We showed that intracellular α-synuclein assemblies, without neurodegeneration, suffice to alter nanoscale diffusion in the striatal ECS.
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inserm-04866532 , version 1 (06-01-2025)

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J. Estaun-Panzano, S. Nandi, Q. Gresil, E. Doudnikoff, C. Mazzocco, et al.. Intracellular α-synuclein assemblies are sufficient to alter nanoscale diffusion in the striatal extracellular space. npj Parkinson's Disease, 2024, 10 (1), pp.236. ⟨10.1038/s41531-024-00850-8⟩. ⟨inserm-04866532⟩
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