Article Dans Une Revue European Journal of Cancer Année : 2025

European consensus-based interdisciplinary guideline for melanoma. Part 1: Diagnostics - Update 2024

1 Eberhard Karls Universität Tübingen = University of Tübingen
2 Unicatt - Università cattolica del Sacro Cuore = Catholic University of the Sacred Heart [Roma]
3 FPUAG - Fondazione Policlinico Universitario A. Gemelli [Rome]
4 UKSH - University Medical Center of Schleswig–Holstein = Universitätsklinikum Schleswig-Holstein
5 First Faculty of Medicine Charles University
6 HIPI (UMR_S_976 / U976) - Immunologie humaine, physiopathologie & immunothérapie
7 AP-HP - Hopital Saint-Louis [AP-HP]
8 OUH - Odense University Hospital
9 King‘s College London
10 Ghent University Hospital
11 ULB - Université libre de Bruxelles
12 HUB-ULB - Hôpital Erasme = Erasmus Hospital = Erasmus Ziekenhuis
13 INCIT - Immunology and New Concepts in ImmunoTherapy
14 Princess Máxima Center for Pediatric Oncology [Utrecht, Netherlands]
15 IRCCS - Centro San Giovanni di Dio, Fatebenefratelli, Brescia
16 UMPCD - University of Medicine and Pharmacy “Carol Davila”
17 Medizinische Universität Wien = Medical University of Vienna
18 Frankfurt University Hospital
19 Maastricht University [Maastricht]
20 Aristotle University of Thessaloniki
21 UNIMORE - Università degli Studi di Modena e Reggio Emilia = University of Modena and Reggio Emilia
22 UAB - Universitat Autònoma de Barcelona = Autonomous University of Barcelona = Universidad Autónoma de Barcelona
23 Hospital Universitario Virgen Macarena [Séville]
24 MV2C - Mount Vernon Cancer Centre [Northwood, UK]
25 UVSQ - Université de Versailles Saint-Quentin-en-Yvelines
26 RUB - Ruhr University Bochum = Ruhr-Universität Bochum
27 NKUA - National and Kapodistrian University of Athens
28 The University of Sydney
29 Royal Prince Alfred Hospital [Sydney, Australia]
30 Centro Hospitalar e Universitário [Coimbra]
31 Azienda Ospedaliero-Universitaria di Parma = Maggiore Hospital in Parma
32 University of Manchester [Manchester]
33 UNIPG - Università degli Studi di Perugia = University of Perugia
34 Ospedale "Santa Maria della Misericordia" = University Hospital "Santa Maria della Misericordia"

Résumé

This guideline was developed in close collaboration with multidisciplinary experts from the European Association of Dermato-Oncology (EADO), the European Dermatology Forum (EDF) and the European Organization for Research and Treatment of Cancer (EORTC). Recommendations for the diagnosis and treatment of melanoma were developed on the basis of systematic literature research and consensus conferences. Cutaneous melanoma (CM) is the most dangerous form of skin tumor and accounts for 90 % of skin cancer mortality. The diagnosis of melanoma can be made clinically and must always be confirmed by dermoscopy. If melanoma is suspected, a histopathological examination is always required. Sequential digital dermoscopy and whole-body photography can be used in high-risk patients to improve the detection of early-stage melanoma. If available, confocal reflectance microscopy can also improve the clinical diagnosis in special cases. Melanoma is classified according to the 8th version of the American Joint Committee on Cancer classification. For thin melanomas up to a tumor thickness of 0.8 mm, no further diagnostic imaging is required. From stage IB, lymph node sonography is recommended, but no further imaging examinations. From stage IIB/C, whole-body examinations with computed tomography or positron emission tomography CT in combination with magnetic resonance imaging of the brain are recommended. From stage IIB/C and higher, a mutation test is recommended, especially for the BRAF V600 mutation. It is important to perform a structured follow-up to detect relapses and secondary primary melanomas as early as possible. A stage-based follow-up regimen is proposed, which in the experience of the guideline group covers the optimal requirements, although further studies may be considered. This guideline is valid until the end of 2026.

Dates et versions

inserm-04851599 , version 1 (20-12-2024)

Identifiants

Citer

Claus Garbe, Teresa Amaral, Ketty Peris, Axel Hauschild, Petr Arenberger, et al.. European consensus-based interdisciplinary guideline for melanoma. Part 1: Diagnostics - Update 2024. European Journal of Cancer, 2025, 215, pp.115152. ⟨10.1016/j.ejca.2024.115152⟩. ⟨inserm-04851599⟩
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