Symptomatic aseptic sinusitis induced by immune checkpoint inhibitors for metastatic melanoma treatment - Inserm - Institut national de la santé et de la recherche médicale
Article Dans Une Revue Immunotherapy Année : 2024

Symptomatic aseptic sinusitis induced by immune checkpoint inhibitors for metastatic melanoma treatment

Résumé

Immune-mediated sinusitis is poorly described and may easily go undiagnosed. We conducted a retrospective, multicenter, national study focusing on symptomatic immune-mediated sinusitis in patients receiving immune checkpoint inhibitors (ICIs) for melanoma treatment. Twelve patients were included (50% women, median age 58 years). Overall, the paraclinical assessment, the inefficacy of antibiotic/antihistaminic treatment, the improvement of symptoms on immunosuppressants and/or after ICI discontinuation, and the presence of multiple concomitant immune-related adverse-events, suggested a noninfectious etiology. Recognizing this toxicity is imperative for limitation of diagnostic wandering and appropriate treatment. However, additional epidemiological studies are needed to assess its prevalence as a potential immune-related adverse-event, and its prognostic value in patients treated with ICIs.
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Dates et versions

inserm-04698488 , version 1 (16-09-2024)

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Sofia Tzoumpa, Béatrice Villette, Florence Granel-Brocard, Caroline Dutriaux, Alexandre Memmi, et al.. Symptomatic aseptic sinusitis induced by immune checkpoint inhibitors for metastatic melanoma treatment. Immunotherapy, 2024, pp.1-9. ⟨10.1080/1750743X.2024.2399498⟩. ⟨inserm-04698488⟩
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