Article Dans Une Revue Journal of Neurochemistry Année : 2019

In vivo molecular imaging of neuroinflammation in Alzheimer's disease

Résumé

It has become increasingly evident that neuroinflammation plays a critical role in the pathophysiology of Alzheimer's disease (AD) and other neurodegenerative disorders. Increased glial cell activation is consistently reported in both rodent models of AD and in AD patients. Moreover, recent genome wide association studies have revealed multiple genes associated with inflammation and immunity are significantly associated with an increased risk of AD development (e.g. TREM2). Non-invasive in vivo detection and tracking of neuroinflammation is necessary to enhance our understanding of the contribution of neuroinflammation to the initiation and progression of AD. Importantly, accurate methods of quantifying neuroinflammation may aid early diagnosis and serve as an output for therapeutic monitoring and disease management. This review details current in vivo imaging biomarkers of neuroinflammation being explored and summarizes both pre-clinical and clinical results from molecular imaging studies investigating the role of neuroinflammation in AD, with a focus on positron emission tomography and magnetic resonance spectroscopy (MRS).

Fichier principal
Vignette du fichier
Journal of Neurochemistry - 2018 - Chaney.pdf (243.09 Ko) Télécharger le fichier
Origine Publication financée par une institution
Licence

Dates et versions

inserm-04688209 , version 1 (04-09-2024)

Licence

Identifiants

Citer

Aisling Chaney, Steve Williams, Herve Boutin. In vivo molecular imaging of neuroinflammation in Alzheimer's disease. Journal of Neurochemistry, 2019, 149 (4), pp.438-451. ⟨10.1111/jnc.14615⟩. ⟨inserm-04688209⟩

Collections

82 Consultations
149 Téléchargements

Altmetric

Partager

  • More