Smaller total and subregional cerebellar volumes in posttraumatic stress disorder: a mega-analysis by the ENIGMA-PGC PTSD workgroup
Ashley A Huggins
(1, 2)
,
C Lexi Baird
(1, 2)
,
Melvin Briggs
(1, 2)
,
Sarah Laskowitz
(1, 2)
,
Ahmed Hussain
(1, 2)
,
Samar Fouda
(3, 1, 2)
,
Courtney Haswell
(1, 2)
,
Delin Sun
(4, 1, 2)
,
Lauren E Salminen
(5, 6)
,
Neda Jahanshad
(6, 5)
,
Sophia I Thomopoulos
(6, 5)
,
Dick J Veltman
(7)
,
Jessie L Frijling
(7, 8)
,
Miranda Olff
(9, 7)
,
Mirjam van Zuiden
(10, 7)
,
Saskia B J Koch
(7, 11)
,
Laura Nawjin
(7)
,
Li Wang
(12, 13)
,
Ye Zhu
(13)
,
Gen Li
(14, 13)
,
Dan J Stein
(15)
,
Jonathan Ipser
(15)
,
Soraya Seedat
(16, 17)
,
Stefan Du Plessis
(16, 17)
,
Leigh L van den Heuvel
(16, 17)
,
Benjamin Suarez-Jimenez
(18)
,
Xi Zhu
(19, 20)
,
Yoojean Kim
(20)
,
Xiaofu He
(19, 20)
,
Sigal Zilcha-Mano
(21)
,
Amit Lazarov
(19, 22)
,
Yuval Neria
(19, 20)
,
Jennifer S Stevens
(23)
,
Kerry J Ressler
(23, 24, 25)
,
Tanja Jovanovic
(23, 26)
,
Sanne J H van Rooij
(23)
,
Negar Fani
(23)
,
Anna R Hudson
(27)
,
Sven C Mueller
(27)
,
Anika Sierk
(28)
,
Antje Manthey
(28)
,
Henrik Walter
(28)
,
Judith K Daniels
(29)
,
Christian Schmahl
(30)
,
Julia I Herzog
(30)
,
Pavel Říha
(31, 32)
,
Ivan Rektor
(32)
,
Lauren a M Lebois
(25, 24)
,
Milissa L Kaufman
(25, 24)
,
Elizabeth A Olson
(25, 24)
,
Justin T Baker
(25, 24)
,
Isabelle M Rosso
(25, 24)
,
Anthony P King
(33)
,
Isreal Liberzon
(34)
,
Mike Angstadt
(35)
,
Nicholas D Davenport
(36)
,
Scott R Sponheim
(36)
,
Seth G Disner
(36)
,
Thomas Straube
(37)
,
David Hofmann
(37)
,
Rongfeng Qi
(38)
,
Guang Ming Lu
(38)
,
Lee A Baugh
(39)
,
Gina L Forster
(39, 40)
,
Raluca M Simons
(39)
,
Jeffrey S Simons
(39)
,
Vincent A Magnotta
(41)
,
Kelene A Fercho
(39)
,
Adi Maron-Katz
(42)
,
Amit Etkin
(42)
,
Andrew S Cotton
(43)
,
Erin N O'Leary
(43)
,
Hong Xie
(43)
,
Xin Wang
(43)
,
Yann Quidé
(44)
,
Wissam El-Hage
(45, 46, 47)
,
Shmuel Lissek
(36)
,
Hannah Berg
(36)
,
Steven Bruce
(48)
,
Josh Cisler
(49)
,
Marisa Ross
(50)
,
Ryan J Herringa
(51)
,
Daniel W Grupe
(51)
,
Jack B Nitschke
(51)
,
Richard J Davidson
(51)
,
Christine L Larson
(52)
,
Terri A Deroon-Cassini
(53)
,
Carissa W Tomas
(53)
,
Jacklynn M Fitzgerald
(54)
,
Jennifer Urbano Blackford
(55, 56)
,
Bunmi O Olatunji
(56)
,
William S Kremen
(57)
,
Michael J Lyons
(58)
,
Carol E Franz
(57)
,
Evan M Gordon
(59)
,
Geoffrey May
(60, 61, 34)
,
Steven M Nelson
(36)
,
Chadi G Abdallah
(62, 63)
,
Ifat Levy
(63, 64)
,
Ilan Harpaz-Rotem
(63, 64)
,
John H Krystal
(63, 64)
,
Emily L Dennis
(65)
,
David F Tate
(65)
,
David X Cifu
(66)
,
William C Walker
(66)
,
Elizabeth A Wilde
(65, 67, 62)
,
Ian H Harding
(68)
,
Rebecca Kerestes
(68)
,
Paul M Thompson
(6)
,
Rajendra Morey
(1, 2)
1
Duke University [Durham]
2 Centers for Aging and Geriatric Research Education and Clinical Center - Department of Medicine [Durham, NC, USA]
3 Duke University School of Medicine [Durham, NC, USA]
4 EdUHK - The Education University of Hong Kong
5 Stevens Institute of Technology [Hoboken]
6 Keck School of Medicine [Los Angeles]
7 Department of Psychiatry
8 Erasmus MC - Erasmus University Medical Center [Rotterdam]
9 ARQ National Psychotrauma Centre [Diemen, the Netherlands]
10 AMC - Academic Medical Center - Academisch Medisch Centrum [Amsterdam]
11 Radboud University Medical Center [Nijmegen]
12 NSRL - National Synchrotron Radiation Laboratory
13 CAS - Chinese Academy of Sciences [Beijing]
14 New York University [Shanghai]
15 University of Cape Town
16 Stellenbosch University
17 South African Medical Research Council [Cape Town]
18 URMC - University of Rochester Medical Center
19 CUMC - Columbia University Medical Center
20 New York State Psychiatric Institute
21 University of Haifa [Haifa]
22 TAU - Tel Aviv University
23 Emory University School of Medicine
24 McLean Hospital [Belmont, Ma.]
25 HMS - Harvard Medical School [Boston]
26 Wayne State University School of Medicine
27 UGENT - Universiteit Gent = Ghent University = Université de Gand
28 Charité - UniversitätsMedizin = Berlin University Medicine
29 University of Groningen [Groningen]
30 NEUROSPIN - Service NEUROSPIN
31 St. Anne’s University Hospital [Brno]
32 MUNI - Masaryk University [Brno]
33 OSU - The Ohio State University [Columbus]
34 Texas A&M University System
35 University of Michigan [Ann Arbor]
36 University of Minnesota Medical School
37 WWU - Westfälische Wilhelms-Universität Münster = University of Münster
38 Medical School (University of Nanjing)
39 USD - University of South Dakota [Vermillion]
40 University of Otago [Dunedin, Nouvelle-Zélande]
41 University of Iowa [Iowa City]
42 Stanford University
43 University of Toledo
44 UNSW - University of New South Wales [Sydney]
45 iBraiN - Imaging, Brain & Neuropsychiatry
46 CIC - Centre d’Investigation Clinique [Tours] CIC 1415
47 CHU Trousseau [Tours]
48 University of Missouri [St. Louis]
49 University of Texas at Austin [Austin]
50 Northwestern University [Evanston]
51 University of Wisconsin-Madison
52 University of Wisconsin–Milwaukee
53 MCW - Medical College of Wisconsin [Milwaukee]
54 Marquette University [Milwaukee]
55 University of Nebraska Medical Center
56 Vanderbilt University [Nashville]
57 UC San Diego - University of California [San Diego]
58 BU - Boston University [Boston]
59 Washington University School of Medicine [Saint Louis, MO]
60 Baylor University
61 UT Dallas - University of Texas at Dallas [Richardson]
62 BCM - Baylor College of Medicine
63 Yale University [New Haven]
64 National Center for PTSD at VA Boston Healthcare System, Boston, MA, USA.
65 School of Medicine [University of Utah, Salt Lake City]
66 VCU - Virginia Commonwealth University
67 George E. Wahlen VA Hospital
68 Monash University [Melbourne]
2 Centers for Aging and Geriatric Research Education and Clinical Center - Department of Medicine [Durham, NC, USA]
3 Duke University School of Medicine [Durham, NC, USA]
4 EdUHK - The Education University of Hong Kong
5 Stevens Institute of Technology [Hoboken]
6 Keck School of Medicine [Los Angeles]
7 Department of Psychiatry
8 Erasmus MC - Erasmus University Medical Center [Rotterdam]
9 ARQ National Psychotrauma Centre [Diemen, the Netherlands]
10 AMC - Academic Medical Center - Academisch Medisch Centrum [Amsterdam]
11 Radboud University Medical Center [Nijmegen]
12 NSRL - National Synchrotron Radiation Laboratory
13 CAS - Chinese Academy of Sciences [Beijing]
14 New York University [Shanghai]
15 University of Cape Town
16 Stellenbosch University
17 South African Medical Research Council [Cape Town]
18 URMC - University of Rochester Medical Center
19 CUMC - Columbia University Medical Center
20 New York State Psychiatric Institute
21 University of Haifa [Haifa]
22 TAU - Tel Aviv University
23 Emory University School of Medicine
24 McLean Hospital [Belmont, Ma.]
25 HMS - Harvard Medical School [Boston]
26 Wayne State University School of Medicine
27 UGENT - Universiteit Gent = Ghent University = Université de Gand
28 Charité - UniversitätsMedizin = Berlin University Medicine
29 University of Groningen [Groningen]
30 NEUROSPIN - Service NEUROSPIN
31 St. Anne’s University Hospital [Brno]
32 MUNI - Masaryk University [Brno]
33 OSU - The Ohio State University [Columbus]
34 Texas A&M University System
35 University of Michigan [Ann Arbor]
36 University of Minnesota Medical School
37 WWU - Westfälische Wilhelms-Universität Münster = University of Münster
38 Medical School (University of Nanjing)
39 USD - University of South Dakota [Vermillion]
40 University of Otago [Dunedin, Nouvelle-Zélande]
41 University of Iowa [Iowa City]
42 Stanford University
43 University of Toledo
44 UNSW - University of New South Wales [Sydney]
45 iBraiN - Imaging, Brain & Neuropsychiatry
46 CIC - Centre d’Investigation Clinique [Tours] CIC 1415
47 CHU Trousseau [Tours]
48 University of Missouri [St. Louis]
49 University of Texas at Austin [Austin]
50 Northwestern University [Evanston]
51 University of Wisconsin-Madison
52 University of Wisconsin–Milwaukee
53 MCW - Medical College of Wisconsin [Milwaukee]
54 Marquette University [Milwaukee]
55 University of Nebraska Medical Center
56 Vanderbilt University [Nashville]
57 UC San Diego - University of California [San Diego]
58 BU - Boston University [Boston]
59 Washington University School of Medicine [Saint Louis, MO]
60 Baylor University
61 UT Dallas - University of Texas at Dallas [Richardson]
62 BCM - Baylor College of Medicine
63 Yale University [New Haven]
64 National Center for PTSD at VA Boston Healthcare System, Boston, MA, USA.
65 School of Medicine [University of Utah, Salt Lake City]
66 VCU - Virginia Commonwealth University
67 George E. Wahlen VA Hospital
68 Monash University [Melbourne]
Ashley A Huggins
- Fonction : Auteur
Courtney Haswell
- Fonction : Auteur
Wissam El-Hage
- Fonction : Auteur
- PersonId : 183525
- IdHAL : wissam-el-hage
- ORCID : 0000-0003-3877-0855
- IdRef : 068549679
Résumé
Although the cerebellum contributes to higher-order cognitive and emotional functions relevant to posttraumatic stress disorder (PTSD), prior research on cerebellar volume in PTSD is scant, particularly when considering subregions that differentially map on to motor, cognitive, and affective functions. In a sample of 4215 adults (PTSD n = 1642; Control n = 2573) across 40 sites from the ENIGMA-PGC PTSD working group, we employed a new state-of-the-art deep-learning based approach for automatic cerebellar parcellation to obtain volumetric estimates for the total cerebellum and 28 subregions. Linear mixed effects models controlling for age, gender, intracranial volume, and site were used to compare cerebellum volumes in PTSD compared to healthy controls (88% trauma-exposed). PTSD was associated with significant grey and white matter reductions of the cerebellum. Compared to controls, people with PTSD demonstrated smaller total cerebellum volume, as well as reduced volume in subregions primarily within the posterior lobe (lobule VIIB, crus II), vermis (VI, VIII), flocculonodular lobe (lobule X), and corpus medullare (all p-FDR < 0.05). Effects of PTSD on volume were consistent, and generally more robust, when examining symptom severity rather than diagnostic status. These findings implicate regionally specific cerebellar volumetric differences in the pathophysiology of PTSD. The cerebellum appears to play an important role in higher-order cognitive and emotional processes, far beyond its historical association with vestibulomotor function. Further examination of the cerebellum in trauma-related psychopathology will help to clarify how cerebellar structure and function may disrupt cognitive and affective processes at the center of translational models for PTSD.
Domaines
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