Modeling Parkinson's Disease in Primates - Inserm - Institut national de la santé et de la recherche médicale Accéder directement au contenu
Article Dans Une Revue Cold Spring Harbor Perspectives in Medicine Année : 2024

Modeling Parkinson's Disease in Primates

Résumé

Decades of research have identified the pathological and pathophysiological hallmarks of Parkinson's disease (PD): profound deficit in brain dopamine and other monoamines, pathological α-synuclein aggregation, synaptic and neuronal network dysfunction, aberrant proteostasis, altered energy homeostasis, inflammation, and neuronal cell death. The purpose of this contribution is to present the phenocopy aspect, pathogenic, and etiologic nonhuman primate (NHP) models of PD to readers with limited prior knowledge of PD so that they are ready to start working on PD. How NHPs, the closest species to man on which we can model diseases, contribute to the knowledge progress and how these models represent an invaluable translational step in therapeutic development are highlighted.
Fichier non déposé

Dates et versions

inserm-04607791 , version 1 (11-06-2024)

Identifiants

Citer

Erwan Bezard, Margaux Teil, Marie-Laure Arotcarena, Gregory Porras, Qin Li, et al.. Modeling Parkinson's Disease in Primates. Cold Spring Harbor Perspectives in Medicine, 2024, pp.a041612. ⟨10.1101/cshperspect.a041612⟩. ⟨inserm-04607791⟩

Collections

INSERM CNRS
10 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Mastodon Facebook X LinkedIn More