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Article Dans Une Revue Annales de Pathologie Année : 2024

Tumeurs nasosinusiennes à translocation

Résumé

In recent years, several nasal cavity and sinus entities have been described with fusion genes. Salivary gland tumors with fusion genes will not be discussed in this article, but it should be kept in mind that accessory salivary glands are present in the nasal cavity and sinuses and can therefore lead to tumoral lesions. Entities with specific or more frequently described rearrangements in the nasal cavities and sinuses are DEK::AFF2 squamous cell carcinomas,;non-intestinal and non-salivary nasosinusal adenocarcinomas, some of which displaying ETV6 gene rearrangements; biphenotypic nasosinusal sarcomas, most of which displaying PAX3 gene rearrangements; and Ewing's adamantinoma-like sarcomas, which display the same rearrangements as conventional Ewing's sarcomas, mainly the EWSR1::FLI1 rearrangement. Each entity will be described morphologically, immunohistochemically, and prognostically.
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Dates et versions

inserm-04504925 , version 1 (14-03-2024)

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Charles Lépine, Aude Trinquet, Marick Laé, Valérie Costes-Martineau. Tumeurs nasosinusiennes à translocation. Annales de Pathologie, 2024, Online ahead of print. ⟨10.1016/j.annpat.2023.12.013⟩. ⟨inserm-04504925⟩
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