Roles of inflammatory cell infiltrate in periprosthetic osteolysis - Inserm - Institut national de la santé et de la recherche médicale Accéder directement au contenu
Article Dans Une Revue Frontiers in Immunology Année : 2023

Roles of inflammatory cell infiltrate in periprosthetic osteolysis

Résumé

Classically, particle-induced periprosthetic osteolysis at the implant–bone interface has explained the aseptic loosening of joint replacement. This response is preceded by triggering both the innate and acquired immune response with subsequent activation of osteoclasts, the bone-resorbing cells. Although particle-induced periprosthetic osteolysis has been considered a foreign body chronic inflammation mediated by myelomonocytic-derived cells, current reports describe wide heterogeneous inflammatory cells infiltrating the periprosthetic tissues. This review aims to discuss the role of those non-myelomonocytic cells in periprosthetic tissues exposed to wear particles by showing original data. Specifically, we discuss the role of T cells (CD3 + , CD4 + , and CD8 + ) and B cells (CD20 + ) coexisting with CD68 + /TRAP − multinucleated giant cells associated with both polyethylene and metallic particles infiltrating retrieved periprosthetic membranes. This review contributes valuable insight to support the complex cell and molecular mechanisms behind the aseptic loosening theories of orthopedic implants.
Fichier principal
Vignette du fichier
fimmu-14-1310262.pdf (2.33 Mo) Télécharger le fichier
Origine Publication financée par une institution
Licence

Dates et versions

inserm-04501796 , version 1 (12-03-2024)

Licence

Identifiants

Citer

Isidora Panez-Toro, Dominique Heymann, François Gouin, Jérôme Amiaud, Marie-Françoise Heymann, et al.. Roles of inflammatory cell infiltrate in periprosthetic osteolysis. Frontiers in Immunology, 2023, 14, pp.1310262. ⟨10.3389/fimmu.2023.1310262⟩. ⟨inserm-04501796⟩
4 Consultations
7 Téléchargements

Altmetric

Partager

Gmail Mastodon Facebook X LinkedIn More