Cumulative Absolute Risk of Subsequent Colorectal Cancer After Abdominopelvic Radiotherapy Among Childhood Cancer Survivors: A PanCareSurFup Study
Emma Heymer
(1)
,
Katarzyna Jóźwiak
(2)
,
Leontien Kremer
(3, 4)
,
David Winter
(1)
,
Florent de Vathaire
(5, 6)
,
Ceren Sunguc
(1)
,
Elaine Sugden
(1)
,
Judith Kok
(3)
,
Helena J.H. van der Pal
(3)
,
Lars Hjorth
(7, 8)
,
Zsuzsanna Jakab
(9)
,
Milena Maule
(10, 11)
,
Riccardo Haupt
(12)
,
Francesca Bagnasco
(12)
,
Monica Terenziani
(13)
,
Ibrahima Diallo
(5, 6)
,
Maria Gunnes
(14, 15)
,
Grit Sommer
(16, 17)
,
Lorna Zadravec Zaletel
(18)
,
Claudia Kuehni
(16, 17, 19)
,
Jeanette Winther
(20, 21, 22)
,
Päivi Lähteenmäki
(23, 24)
,
Thorgerdur Gudmundsdottir
(20, 25)
,
Rodrigue Allodji
(5, 6)
,
Roderick Skinner
(26, 27, 28)
,
Cécile Ronckers
(3, 29)
,
Michael Hawkins
(1)
,
Raoul Reulen
(1)
,
Jop Teepen
(3)
1
University of Birmingham [Birmingham]
2 MHB Theodor Fontane - Medizinische Hochschule Brandenburg Theodor Fontane / Brandenburg Medical School Theodor-Fontane
3 Princess Máxima Center for Pediatric Oncology
4 Academic Medical Center - Emma Children's Hospital [Amsterdam, Netherlands]
5 CESP - Centre de recherche en épidémiologie et santé des populations
6 IGR - Institut Gustave Roussy
7 Lund University
8 Skane University Hospital [Lund]
9 Semmelweis University [Budapest]
10 UNITO - Università degli studi di Torino = University of Turin
11 A.O.U - Città della Salute e della Scienza di Torino
12 IRCCS Istituto Giannina Gaslini [Genoa, Italy]
13 IRCCS Istituto Nazionale dei Tumori [Milano]
14 Oslo University Hospital [Oslo]
15 Cancer Registry of Norway
16 ISPM - Institute of Social and Preventive Medicine [Bern]
17 UNIBE - Universität Bern / University of Bern
18 Institute of Oncology [Ljubljana]
19 Inselspital Bern
20 DCSRC - Danish Cancer Society Research Center [Copenhagen, Denmark]
21 Aarhus University [Aarhus]
22 Aarhus University Hospital
23 University of Turku
24 TYKS - Turku University Hospital
25 Landspitali National University Hospital of Iceland
26 Great North Children’s Hospital [Newcastle Upon Tyne, UK]
27 Newcastle Upon Tyne Hospitals NHS Foundation Trust
28 Newcastle University [Newcastle]
29 OFFIS - Carl Von Ossietzky Universität Oldenburg = Carl von Ossietzky University of Oldenburg
2 MHB Theodor Fontane - Medizinische Hochschule Brandenburg Theodor Fontane / Brandenburg Medical School Theodor-Fontane
3 Princess Máxima Center for Pediatric Oncology
4 Academic Medical Center - Emma Children's Hospital [Amsterdam, Netherlands]
5 CESP - Centre de recherche en épidémiologie et santé des populations
6 IGR - Institut Gustave Roussy
7 Lund University
8 Skane University Hospital [Lund]
9 Semmelweis University [Budapest]
10 UNITO - Università degli studi di Torino = University of Turin
11 A.O.U - Città della Salute e della Scienza di Torino
12 IRCCS Istituto Giannina Gaslini [Genoa, Italy]
13 IRCCS Istituto Nazionale dei Tumori [Milano]
14 Oslo University Hospital [Oslo]
15 Cancer Registry of Norway
16 ISPM - Institute of Social and Preventive Medicine [Bern]
17 UNIBE - Universität Bern / University of Bern
18 Institute of Oncology [Ljubljana]
19 Inselspital Bern
20 DCSRC - Danish Cancer Society Research Center [Copenhagen, Denmark]
21 Aarhus University [Aarhus]
22 Aarhus University Hospital
23 University of Turku
24 TYKS - Turku University Hospital
25 Landspitali National University Hospital of Iceland
26 Great North Children’s Hospital [Newcastle Upon Tyne, UK]
27 Newcastle Upon Tyne Hospitals NHS Foundation Trust
28 Newcastle University [Newcastle]
29 OFFIS - Carl Von Ossietzky Universität Oldenburg = Carl von Ossietzky University of Oldenburg
Emma Heymer
- Fonction : Auteur
- PersonId : 1297258
- ORCID : 0000-0001-5115-0293
Katarzyna Jóźwiak
- Fonction : Auteur
- PersonId : 1346127
- ORCID : 0000-0002-9614-6586
David Winter
- Fonction : Auteur
- PersonId : 1297194
- ORCID : 0000-0002-1597-4081
Florent de Vathaire
- Fonction : Auteur
- PersonId : 1162629
- IdHAL : florent-de-vathaire
- ORCID : 0000-0002-8374-9281
Judith Kok
- Fonction : Auteur
- PersonId : 1297212
- ORCID : 0000-0002-6007-7195
Helena J.H. van der Pal
- Fonction : Auteur
- PersonId : 1297210
- ORCID : 0000-0003-2253-2115
Lars Hjorth
- Fonction : Auteur
- PersonId : 1297215
- ORCID : 0000-0002-8302-7174
Zsuzsanna Jakab
- Fonction : Auteur
- PersonId : 1297213
- ORCID : 0000-0002-5410-1187
Milena Maule
- Fonction : Auteur
- PersonId : 1260538
- ORCID : 0000-0003-2142-1288
Riccardo Haupt
- Fonction : Auteur
- PersonId : 1260544
- ORCID : 0000-0003-0571-8460
Francesca Bagnasco
- Fonction : Auteur
- PersonId : 1260536
- ORCID : 0000-0003-1601-9518
Ibrahima Diallo
- Fonction : Auteur
- PersonId : 1297195
- ORCID : 0000-0002-8272-8817
Grit Sommer
- Fonction : Auteur
- PersonId : 1297208
- ORCID : 0000-0002-4205-7932
Lorna Zadravec Zaletel
- Fonction : Auteur
- PersonId : 1260542
- ORCID : 0000-0002-4423-0276
Claudia Kuehni
- Fonction : Auteur
- PersonId : 804838
- ORCID : 0000-0001-8957-2002
- IdRef : 186420374
Jeanette Winther
- Fonction : Auteur
- PersonId : 1297214
- ORCID : 0000-0002-3440-5108
Päivi Lähteenmäki
- Fonction : Auteur
- PersonId : 1260541
- ORCID : 0000-0002-5500-9606
Rodrigue Allodji
- Fonction : Auteur
- PersonId : 4839
- IdHAL : rodrigue-setcheou-allodji
- ORCID : 0000-0002-1895-8415
Roderick Skinner
- Fonction : Auteur
- PersonId : 1297207
- ORCID : 0000-0002-1162-675X
Cécile Ronckers
- Fonction : Auteur
- PersonId : 1260537
- ORCID : 0000-0003-3524-4657
Michael Hawkins
- Fonction : Auteur
- PersonId : 1297216
- ORCID : 0000-0001-6496-4800
Raoul Reulen
- Fonction : Auteur
- PersonId : 1297193
- ORCID : 0000-0002-7328-0467
Jop Teepen
- Fonction : Auteur
- PersonId : 1297201
- ORCID : 0000-0002-2647-2677
Résumé
PURPOSE Childhood cancer survivors are at the risk of developing subsequent colorectal cancers (CRCs), but the absolute risks by treatment modality are uncertain. We quantified the absolute risks by radiotherapy treatment characteristics using clinically accessible data from a Pan-European wide case-control study nested within a large cohort of childhood cancer survivors: the PanCareSurFup Study. METHODS Odds ratios (ORs) from a case-control study comprising 143 CRC cases and 143 controls nested within a cohort of 69,460 survivors were calculated. These, together with standardized incidence ratios for CRC for this cohort and European general population CRC incidence rates and survivors' mortality rates, were used to estimate cumulative absolute risks (CARs) by attained age for different categories of radiation to the abdominopelvic area. RESULTS Overall, survivors treated with abdominopelvic radiotherapy treatment (ART) were three times more likely to develop a subsequent CRC than those who did not receive ART (OR, 3.1 [95% CI, 1.4 to 6.6]). For male survivors treated with ART, the CAR was 0.27% (95% CI, 0.17 to 0.59) by age 40 years, 1.08% (95% CI, 0.69 to 2.34) by age 50 years (0.27% expected in the general population), and 3.7% (95% CI, 2.36 to 7.80) by age 60 years (0.95% expected). For female survivors treated with ART, the CAR was 0.29% (95% CI, 0.18 to 0.62) by age 40 years, 1.03% (95% CI, 0.65 to 2.22) by age 50 years (0.27% expected), and 3.0% (95% CI, 1.91 to 6.37) by age 60 years (0.82% expected). CONCLUSION We demonstrated that by age 40 years survivors of childhood cancer treated with ART already have a similar risk of CRC as those age 50 years in the general population for whom population-based CRC screening begins in many countries. This information should be used in the development of survivorship guidelines for the risk stratification of survivors concerning CRC risk.