Longitudinal Associations between Prenatal Exposure to Phthalates and Steroid Hormones in Maternal Hair Samples from the SEPAGES Cohort
Résumé
Abstract
We aimed to assess phthalate-hormone associations in the new-generation SEPAGES cohort (2014-2017, France) using improved exposure and outcome assessments. Metabolites from 7 phthalate compounds and the replacement di(isononyl)cyclohexane-1,2-dicarboxylate (DINCH) were measured in within-subject pools of repeated urine samples collected at the second and third pregnancy trimesters (≈21 samples/trimester). Metabolites from 5 steroid hormones were measured in maternal hair samples collected at delivery reflecting on cumulative levels over the previous weeks-months. Adjusted linear regression and bayesian weighted quantile sum (BWQS) mixture models were performed. Each doubling in third trimester urinary MBzP concentrations was associated with average increases of 13.3% (95%CI: 2.65, 24.9) for ∑cortisol, 10.0% (95%CI: 0.26, 20.7) for ∑cortisone, 17.3% (95%CI: 1.67, 35.4) for 11-dehydrocorticosterone and 16.2% (95%CI: 2.20, 32.1) for testosterone, together with a suggestive 10.5% (95%CI: -1.57, 24.1) increase in progesterone levels. Each doubling in second trimester urinary di-isononyl-phthalate (∑DiNP) concentrations was inversely associated with testosterone levels (-11.6%; 95%CI: -21.6, -0.31). For most hormones, a non-significant trend towards a positive phthalate mixture effect was observed at the third but not the second trimester. Our study showed that exposure to some phthalate metabolites, especially MBzP, may affect adrenal and reproductive hormone levels during pregnancy.
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Origine | Fichiers produits par l'(les) auteur(s) |
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