Identification of the human KIF13A gene homologous to Drosophila kinesin-73 and candidate for schizophrenia
Résumé
Several studies have reported significant linkage for schizophrenia on 6p23, with a maximum lod score between D6S274 and D6S285. In this paper, we present a new human kinesin gene localized in this 2-cM interval. This gene, termed KIF13A, belongs to the unc-104/KIF1A kinesin subfamily and represents the orthologue of Drosophila kinesin-73. Several alternative transcripts are differentially expressed in human tissues, probably reflecting differences in cargo binding and transport of corresponding proteins. During early mouse development, its homologue (Kif13A) is expressed essentially in the central nervous system. In Caenorhabditis elegans, the unc-104 gene is involved in axonal anterograde transport, and null mutants present several behavioral defects. The putative function and genomic localization of KIF13A make this gene an interesting candidate for genetic predisposition to schizophrenia. We provide sequences of 20 single-nucleotide polymorphisms localized within KIF13A to test for association studies between this gene and schizophrenia.
Mots clés
Humans
Schizophrenia
Animals
Mice
Nerve Tissue Proteins
Genetic Predisposition to Disease
Female
Male
Polymorphism
Single Nucleotide
Sequence Analysis
DNA
RNA
Messenger
Amino Acid Sequence
Carrier Proteins
Complementary
Molecular Sequence Data
Sequence Homology
Amino Acid
Gene Expression Regulation
Developmental
Phylogeny
Sequence Alignment
Tissue Distribution
Cloning
Molecular
Databases
Factual
Drosophila Proteins
Embryo
Mammalian
In Situ Hybridization
Kinesins