Genetic and psychosocial stressors have independent effects on the level of subclinical psychosis: findings from the multinational EU-GEI study - Inserm - Institut national de la santé et de la recherche médicale Accéder directement au contenu
Article Dans Une Revue Epidemiology and Psychiatric Sciences Année : 2022

Genetic and psychosocial stressors have independent effects on the level of subclinical psychosis: findings from the multinational EU-GEI study

1 Fondation FondaMental [Créteil]
2 CHU Henri Mondor [Créteil]
3 U955 Inserm - UPEC - IMRB - "Neuropsychiatrie translationnelle" [Créteil]
4 AP-HP Hôpital universitaire Robert-Debré [Paris]
5 UCL - University College of London [London]
6 Hôpital Henri Mondor
7 LPPS (URP_4057) - Laboratoire de Psychopathologie et Processus de Santé
8 UNIVR - Università degli studi di Verona = University of Verona
9 UMCG - University Medical Center Groningen [Groningen]
10 Amsterdam UMC - Amsterdam University Medical Center
11 AIMH - Arkin Institute for Mental Health [Amsterdam, The Netherlands]
12 UNIBO - Alma Mater Studiorum Università di Bologna = University of Bologna
13 University of Barcelona
14 IDIBAPS - Institut d'Investigacions Biomèdiques August Pi i Sunyer
15 CIBER-SAM - Centro de Investigación Biomédica en Red Salud Mental [Madrid]
16 MSSM - Icahn School of Medicine at Mount Sinai [New York]
17 LHUS - Emilia-Romagna Regional Health Service, Department of Mental Health and Pathological Addictions, Local Health Authority [Bologna,Italy].
18 Hospital General Universitario "Gregorio Marañón" [Madrid]
19 UCM - Universidad Complutense de Madrid = Complutense University of Madrid [Madrid]
20 IDIS - Instituto de Investigación Sanitaria de Santiago de Compostela / Health Research Institute of Santiago de Compostela
21 CHUS - Complejo Hospitalario Universitario de Santiago de Compostela [Saint-Jacques-de-Compostelle, Espagne]
22 University of Oviedo
23 ISPA - Instituto de Investigación Sanitaria del Principado de Asturias [Oviedo, Spain]
24 USP - Universidade de São Paulo = University of São Paulo
25 SLAM - South London and Maudsley NHS Mental Health Foundation Trust
26 Institute of Psychiatry, Psychology & Neuroscience, King's College London
27 CAM - University of Cambridge [UK]
28 CPFT - Cambridgeshire & Peterborough NHS Foundation Trust [Cambridge]
29 Università degli studi di Palermo - University of Palermo
30 UV - Universitat de València
31 INCLIVA - Biomedical Research Institute [Valencia, Spain]
32 MUMC - Maastricht University Medical Centre
33 GGZ Rivierduinen - Rivierduinen Institute for Mental Health Care [Leiden, Netherlands]
34 IMRB - Institut Mondor de Recherche Biomédicale
35 EPSMB - Établissement Public de Santé Maison Blanche [Paris]
36 CHU Clermont-Ferrand
37 NPsy-Sydo - Neuro-Psycho Pharmacologie des Systèmes Dopimanégiques sous-corticaux
38 Universiteit Utrecht / Utrecht University [Utrecht]
J B Kirkbride

Résumé

Aims. Gene x environment (G×E) interactions, i.e. genetic modulation of the sensitivity to environmental factors and/or environmental control of the gene expression, have not been reliably established regarding aetiology of psychotic disorders. Moreover, recent studies have shown associations between the polygenic risk scores for schizophrenia (PRS-SZ) and some risk factors of psychotic disorders, challenging the traditional gene v. environment dichotomy. In the present article, we studied the role of GxE interaction between psychosocial stressors (childhood trauma, stressful life-events, self-reported discrimination experiences and low social capital) and the PRS-SZ on subclinical psychosis in a population-based sample. Methods. Data were drawn from the EUropean network of national schizophrenia networks studying Gene-Environment Interactions (EU-GEI) study, in which subjects without psychotic disorders were included in six countries. The sample was restricted to European descendant subjects (n = 706). Subclinical dimensions of psychosis (positive, negative, and depressive) were measured by the Community Assessment of Psychic Experiences (CAPE) scale. Associations between the PRS-SZ and the psychosocial stressors were tested. For each dimension, the interactions between genes and environment were assessed using linear models and comparing explained variances of 'Genetic' models (solely fitted with PRS-SZ), 'Environmental' models (solely fitted with each environmental stressor), 'Independent' models (with PRS-SZ and each environmental factor), and 'Interaction' models (Independent models plus an interaction term between the PRS-SZ and each environmental factor). Likelihood ration tests (LRT) compared the fit of the different models. Results. There were no genes-environment associations. PRS-SZ was associated with positive dimensions (β = 0.092, R 2 = 7.50%), and most psychosocial stressors were associated with all three subclinical psychotic dimensions (except social capital and positive dimension). Concerning the positive dimension, Independent models fitted better than Environmental and Genetic models. No significant GxE interaction was observed for any dimension. Conclusions. This study in subjects without psychotic disorders suggests that (i) the aetiological continuum hypothesis could concern particularly the positive dimension of subclinical psychosis, (ii) genetic and environmental factors have independent effects on the level of this positive dimension, (iii) and that interactions between genetic and individual environmental factors could not be identified in this sample.
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Origine : Publication financée par une institution
Licence : CC BY - Paternité

Dates et versions

inserm-04197690 , version 1 (06-09-2023)

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Citer

Baptiste Pignon, H. Peyre, A. Ayrolles, J B Kirkbride, Stéphane Jamain, et al.. Genetic and psychosocial stressors have independent effects on the level of subclinical psychosis: findings from the multinational EU-GEI study. Epidemiology and Psychiatric Sciences, 2022, 31, pp.e68. ⟨10.1017/s2045796022000464⟩. ⟨inserm-04197690⟩
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