Facial Emotion Recognition in Psychosis and Associations With Polygenic Risk for Schizophrenia: Findings From the Multi-Center EU-GEI Case–Control Study
Giada Tripoli
(1, 2)
,
Diego Quattrone
(2, 3, 4, 5)
,
Laura Ferraro
(1)
,
Charlotte Gayer-Anderson
(2)
,
Caterina La Cascia
(1)
,
Daniele La Barbera
(1)
,
Crocettarachele Sartorio
(1)
,
Fabio Seminerio
(1)
,
Victoria Rodriguez
(2)
,
Ilaria Tarricone
(6)
,
Domenico Berardi
(6)
,
Stéphane Jamain
(7)
,
Celso Arango
(8, 9, 10, 11)
,
Andrea Tortelli
(12)
,
Pierre-Michel Llorca
(13)
,
Lieuwe de Haan
(14)
,
Eva Velthorst
(15, 14)
,
Julio Bobes
(16, 11)
,
Miquel Bernardo
(17, 18, 11)
,
Julio Sanjuán
(19, 11)
,
Jose Luis Santos
(20)
,
Manuel Arrojo
(21, 22)
,
Cristina Marta Del-Ben
(23)
,
Paulo Rossi Menezes
(23)
,
Els van der Ven
(24, 25)
,
Peter B Jones
(26, 27)
,
Hannah E Jongsma
(28)
,
James B Kirkbride
(28)
,
Sarah Tosato
(29)
,
Antonio Lasalvia
(30)
,
Alex Richards
(31, 32)
,
Michael O’donovan
(31, 32)
,
Bart P F Rutten
(24)
,
Jim van Os
(24, 33, 1, 34)
,
Craig Morgan
(2)
,
Pak C Sham
(35, 2, 36)
,
Marta Di Forti
(2, 4, 5)
,
Robin M Murray
(2)
,
Graham K Murray
(26, 27, 37, 38)
1
Università degli studi di Palermo - University of Palermo
2 Institute of Psychiatry, Psychology & Neuroscience, King's College London
3 Universität Heidelberg [Heidelberg] = Heidelberg University
4 NIHR Biomedical Research Centre [London]
5 SLAM - South London and Maudsley NHS Mental Health Foundation Trust
6 UNIBO - Alma Mater Studiorum Università di Bologna = University of Bologna
7 U955 Inserm - UPEC - IMRB - "Neuropsychiatrie translationnelle" [Créteil]
8 UCM - Universidad Complutense de Madrid = Complutense University of Madrid [Madrid]
9 Hospital General Universitario "Gregorio Marañón" [Madrid]
10 IiSGM - Instituto de Investigación Sanitaria Gregorio Marañón / Institute of Health Research Gregorio Marañón [Madrid, Spain]
11 CIBER-SAM - Centro de Investigación Biomédica en Red Salud Mental [Madrid]
12 EPSMB - Établissement Public de Santé Maison Blanche [Paris]
13 UCA - Université Clermont Auvergne
14 UvA - University of Amsterdam [Amsterdam] = Universiteit van Amsterdam
15 MSSM - Icahn School of Medicine at Mount Sinai [New York]
16 Universidad de Oviedo = University of Oviedo
17 University of Barcelona
18 IDIBAPS - Institut d'Investigacions Biomèdiques August Pi i Sunyer
19 UV - Universitat de València
20 HVDL - Hospital Virgen de La Luz [Cuenca, Spain]
21 IDIS - Instituto de Investigación Sanitaria de Santiago de Compostela / Health Research Institute of Santiago de Compostela
22 CHUS - Complejo Hospitalario Universitario de Santiago de Compostela [Saint-Jacques-de-Compostelle, Espagne]
23 USP - Universidade de São Paulo = University of São Paulo
24 MUMC - Maastricht University Medical Centre
25 VU - Vrije Universiteit Amsterdam [Amsterdam]
26 CAM - University of Cambridge [UK]
27 CPFT - Cambridgeshire & Peterborough NHS Foundation Trust [Cambridge]
28 UCL - University College of London [London]
29 UNIVR - Università degli studi di Verona = University of Verona
30 Azienda Ospedaliera Universitaria Integrata of Verona
31 Cardiff University
32 MRC Centre for Neuropsychiatric Genetics and Genomics
33 UMCU - University Medical Center [Utrecht]
34 Brain Centre Rudolf Magnus [Utrecht]
35 HKU - The University of Hong Kong
36 Li Kashing Faculty of Medicine [Hong Kong]
37 UQ [All campuses : Brisbane, Dutton Park Gatton, Herston, St Lucia and other locations] - The University of Queensland
38 Institute for Molecular Bioscience
2 Institute of Psychiatry, Psychology & Neuroscience, King's College London
3 Universität Heidelberg [Heidelberg] = Heidelberg University
4 NIHR Biomedical Research Centre [London]
5 SLAM - South London and Maudsley NHS Mental Health Foundation Trust
6 UNIBO - Alma Mater Studiorum Università di Bologna = University of Bologna
7 U955 Inserm - UPEC - IMRB - "Neuropsychiatrie translationnelle" [Créteil]
8 UCM - Universidad Complutense de Madrid = Complutense University of Madrid [Madrid]
9 Hospital General Universitario "Gregorio Marañón" [Madrid]
10 IiSGM - Instituto de Investigación Sanitaria Gregorio Marañón / Institute of Health Research Gregorio Marañón [Madrid, Spain]
11 CIBER-SAM - Centro de Investigación Biomédica en Red Salud Mental [Madrid]
12 EPSMB - Établissement Public de Santé Maison Blanche [Paris]
13 UCA - Université Clermont Auvergne
14 UvA - University of Amsterdam [Amsterdam] = Universiteit van Amsterdam
15 MSSM - Icahn School of Medicine at Mount Sinai [New York]
16 Universidad de Oviedo = University of Oviedo
17 University of Barcelona
18 IDIBAPS - Institut d'Investigacions Biomèdiques August Pi i Sunyer
19 UV - Universitat de València
20 HVDL - Hospital Virgen de La Luz [Cuenca, Spain]
21 IDIS - Instituto de Investigación Sanitaria de Santiago de Compostela / Health Research Institute of Santiago de Compostela
22 CHUS - Complejo Hospitalario Universitario de Santiago de Compostela [Saint-Jacques-de-Compostelle, Espagne]
23 USP - Universidade de São Paulo = University of São Paulo
24 MUMC - Maastricht University Medical Centre
25 VU - Vrije Universiteit Amsterdam [Amsterdam]
26 CAM - University of Cambridge [UK]
27 CPFT - Cambridgeshire & Peterborough NHS Foundation Trust [Cambridge]
28 UCL - University College of London [London]
29 UNIVR - Università degli studi di Verona = University of Verona
30 Azienda Ospedaliera Universitaria Integrata of Verona
31 Cardiff University
32 MRC Centre for Neuropsychiatric Genetics and Genomics
33 UMCU - University Medical Center [Utrecht]
34 Brain Centre Rudolf Magnus [Utrecht]
35 HKU - The University of Hong Kong
36 Li Kashing Faculty of Medicine [Hong Kong]
37 UQ [All campuses : Brisbane, Dutton Park Gatton, Herston, St Lucia and other locations] - The University of Queensland
38 Institute for Molecular Bioscience
Laura Ferraro
- Fonction : Auteur
- PersonId : 1280877
- ORCID : 0000-0002-1205-2356
Charlotte Gayer-Anderson
- Fonction : Auteur
- PersonId : 1280878
- ORCID : 0000-0003-1636-889X
Stéphane Jamain
- Fonction : Auteur
- PersonId : 745408
- IdHAL : stephane-jamain
- ORCID : 0000-0002-4321-4100
- IdRef : 07777146X
Celso Arango
- Fonction : Auteur
Pierre-Michel Llorca
- Fonction : Auteur
- PersonId : 781416
- ORCID : 0000-0001-7438-8990
- IdRef : 05967797X
James B Kirkbride
- Fonction : Auteur
- PersonId : 1280879
- ORCID : 0000-0003-3401-0824
Antonio Lasalvia
- Fonction : Auteur
- PersonId : 1280880
- ORCID : 0000-0001-9963-6081
Alex Richards
- Fonction : Auteur
- PersonId : 1280881
- ORCID : 0000-0003-3218-7247
Résumé
population-based controls completed assessments of the Degraded Facial Affect Recognition Task (DFAR) and a subsample of 524 FEP and 899 controls provided blood or saliva samples from which we extracted DNA, performed genotyping and computed polygenic risk scores for schizophrenia (SZ), bipolar disorder (BD), and major depressive disorder (MD). Study Results: A worse ability to globally recognize facial emotion expressions was found in patients compared with controls [B= −1.5 (0.6), 95% CI −2.7 to −0.3], with evidence for stronger effects on negative emotions (fear [B = −3.3 (1.1), 95% CI −5.3 to −1.2] and anger [B = −2.3 (1.1), 95% CI −4.6 to −0.1]) than on happiness [B = 0.3 (0.7), 95% CI −1 to 1.7]. Pooling all participants, and controlling for confounds including case/control status, facial anger recognition was associated significantly with Schizophrenia Polygenic Risk Score (SZ PRS) [B = −3.5 (1.7), 95% CI −6.9 to −0.2]. Conclusions: Psychosis is associated with impaired recognition of fear and anger, and higher SZ PRS is associated with worse facial anger recognition. Our findings provide evidence that facial emotion recognition of anger might play a role as an intermediate phenotype for psychosis.
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