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Article Dans Une Revue (Data Paper) British Journal of Haematology Année : 2019

Plasma histamine elevation in a large cohort of sickle cell disease patients

Sarah Mattioni
  • Fonction : Auteur
Gilles Grateau
  • Fonction : Auteur
Sophie Georgin-Lavialle
  • Fonction : co dernier-auteur

Résumé

The role of mast cells has been questioned in sickle cell disease (SCD). We performed a prospective study evaluating plasma histamine and tryptase levels in a cohort of paediatric and adult patients, in steady state (n = 132) and during vasoocclusive crisis (VOC) (n = 121). Histamine level was elevated in 18% of patients in steady state and in 61% during VOC. Median histamine level was significantly higher during VOC than in steady state (24Á1 [7Á0-45Á0] vs 9Á6 [6Á2-14Á4] nmol/l, P < 0Á0001). Tryptase level was slightly increased during VOC without reaching pathological values. These results suggest a role of mast cell activation in SCD pathophysiology.

Domaines

Immunité innée

Dates et versions

inserm-04050903 , version 1 (22-08-2023)

Licence

Copyright (Tous droits réservés)

Identifiants

Citer

Slimane Allali, François Lionnet, Sarah Mattioni, Jacques Callebert, Katia Stankovic Stojanovic, et al.. Plasma histamine elevation in a large cohort of sickle cell disease patients. British Journal of Haematology, 2019, 186 (1), pp.125-129. ⟨10.1111/bjh.15900⟩. ⟨inserm-04050903⟩
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