Association studies in outbred mice in a new era of full-genome sequencing - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles Mammalian Genome Year : 2012

Association studies in outbred mice in a new era of full-genome sequencing

Abstract

Thousands of loci that contribute to quantitative traits in outbred crosses of mice have been reported over the last two decades. In this review we discuss how outbred mouse populations can be used to map and identify the genes and sequence variants that give rise to quantitative variation. We discuss heterogeneous stocks, the diversity outbred, and commercially available outbred populations of mice. All of these populations are descended from a small number of progenitor strains. The availability of the complete sequence of laboratory strains means that in many cases it will be possible to reconstruct the genomes of the outbred animals so that in a genetic association study we can detect the effect of all variants, a situation that has so far eluded studies in completely outbred populations. These resources constitute a major advance and make it possible to progress from a quantitative trait locus to a gene at an unprecedented speed.
Fichier principal
Vignette du fichier
s00335-012-9409-z.pdf (263.31 Ko) Télécharger le fichier
Origin : Publication funded by an institution

Dates and versions

inserm-03949489 , version 1 (20-01-2023)

Identifiers

Cite

Binnaz Yalcin, Jonathan Flint. Association studies in outbred mice in a new era of full-genome sequencing. Mammalian Genome, 2012, 23, pp.719 - 726. ⟨10.1007/s00335-012-9409-z⟩. ⟨inserm-03949489⟩
1 View
4 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More