Genetic dissection of a behavioral quantitative trait locus shows that Rgs2 modulates anxiety in mice - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles Nature Genetics Year : 2004

Genetic dissection of a behavioral quantitative trait locus shows that Rgs2 modulates anxiety in mice

Abstract

Here we present a strategy to determine the genetic basis of variance in complex phenotypes that arise from natural, as opposed to induced, genetic variation in mice. We show that a commercially available strain of outbred mice, MF1, can be treated as an ultrafine mosaic of standard inbred strains and accordingly used to dissect a known quantitative trait locus influencing anxiety. We also show that this locus can be subdivided into three regions, one of which contains Rgs2, which encodes a regulator of G protein signaling. We then use quantitative complementation to show that Rgs2 is a quantitative trait gene. This combined genetic and functional approach should be applicable to the analysis of any quantitative trait.
Embargoed file
Embargoed file
Visibility date is undetermined

Dates and versions

inserm-03949431 , version 1 (20-01-2023)

Identifiers

Cite

Binnaz Yalcin, Saffron a G Willis-Owen, Jan Fullerton, Anjela Meesaq, Robert M Deacon, et al.. Genetic dissection of a behavioral quantitative trait locus shows that Rgs2 modulates anxiety in mice. Nature Genetics, 2004, 36, pp.1197 - 1202. ⟨10.1038/ng1450⟩. ⟨inserm-03949431⟩

Collections

INSERM
2 View
0 Download

Altmetric

Share

Gmail Mastodon Facebook X LinkedIn More