Yield of FDG PET/CT for Defining the Extent of Disease in Patients with Kaposi Sarcoma - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles Cancers Year : 2022

Yield of FDG PET/CT for Defining the Extent of Disease in Patients with Kaposi Sarcoma

Abstract

Background: Positron emission tomography/computed tomography with fluorodeoxyglucose (F-18) (FDG PET/CT) is increasingly used in Kaposi sarcoma (KS), but its value has not been assessed. Objectives: In this study, we aimed to evaluate the diagnostic accuracy of FDG PET/CT to define the extent of disease in KS. Methods: Consecutive patients with KS referred to our department for FDG PET/CT were included. The diagnostic accuracy of FDG PET/CT for cutaneous and extra-cutaneous KS staging was assessed on a per lesion basis compared to staging obtained from clinical examination, standard imaging, endoscopy, histological analyses, and follow-up. Results: From 2007 to 2017, 75 patients with FDG PET/CT were analyzed. The sensitivity and specificity of FDG PET/CT for the overall detection of KS lesions were 71 and 98%, respectively. Sensitivity and specificity were 100 and 85% for lymph nodes, 87 and 98% for bone, 87 and 100% for lungs, and 100 and 100% for muscle involvement, whereas sensitivity was only 17% to detect KS digestive involvement. The sensitivity of the diagnostic for KS cutaneous involvement increased from 73 to 88% when using a whole-body examination. Conclusion: FDG PET/CT showed good sensitivity and specificity for KS staging (digestive involvement excepted) and could be used for staging patients with active KS.
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Dates and versions

inserm-03924862 , version 1 (05-01-2023)

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Louise Pesqué, Julie Delyon, Coralie Lheure, Barouyr Baroudjian, Maxime Battistella, et al.. Yield of FDG PET/CT for Defining the Extent of Disease in Patients with Kaposi Sarcoma. Cancers, 2022, 14 (9), pp.2189. ⟨10.3390/cancers14092189⟩. ⟨inserm-03924862⟩
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