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Journal Articles Acta Psychiatrica Scandinavica Year : 2017

A re-examination of antidepressant treatment-emergent mania in bipolar disorders: evidence of gender differences

Abstract

Objective: To explore the prevalence and clinical profile of males and females who develop antidepressant treatment-emergent mania (ATEM). Method: From an original sample of 754 patients with BD, we identified ATEM+ cases (n = 75) and ATEM- controls (n = 135) that met stringent criteria. We specifically examined the combinations of clinical factors that best classified males and females as ATEM+ cases. Results: Seventy-five individuals were classified as ATEM+; 87% of ATEM events occurred during antidepressant monotherapy. Regression analyses demonstrated that the presence of an alcohol and/or substance use disorder [Odds Ratio (OR) 6.37], a history of one or more suicide attempts (OR 4.19) and higher number of depressive episodes per year of illness (OR 1.71) correctly classified 73% of males. In contrast, 84% of females were correctly classified on the basis of a positive history of thyroid disorder (OR 3.23), a positive family history of BD I (OR 2.68) and depressive onset polarity (OR 2.01). Conclusion: Using stringent definitions of ATEM status to reduce the probability of inclusion of false-positive cases and false-negative controls, we identified for the first time that the risk profiles for the development of an ATEM differ significantly according to gender.
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Dates and versions

inserm-03854505 , version 1 (15-11-2022)

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J. Scott, C. Brichant-Petitjean, B. Etain, C. Henry, J.-P. Kahn, et al.. A re-examination of antidepressant treatment-emergent mania in bipolar disorders: evidence of gender differences. Acta Psychiatrica Scandinavica, 2017, 135 (5), pp.479-488. ⟨10.1111/acps.12728⟩. ⟨inserm-03854505⟩
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