Circulating microRNAs as Diagnostic Markers in Primary Aldosteronism - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles Cancers Year : 2021

Circulating microRNAs as Diagnostic Markers in Primary Aldosteronism

Scott M Mackenzie
Hannah Saunders
  • Function : Author
  • PersonId : 1184051
Josie C van Kralingen
  • Function : Author
  • PersonId : 1184052
Stacy Robertson
  • Function : Author
  • PersonId : 1184053
Alexandra Riddell
  • Function : Author
  • PersonId : 1184054
Eleanor Davies
  • Function : Author
  • PersonId : 1184055

Abstract

Primary aldosteronism (PA) is a common and highly treatable condition, usually resulting from adrenocortical tumorous growth or hyperplasia. PA is currently underdiagnosed owing to its complex and protracted diagnostic procedures. A simplified biomarker-based test would be highly valuable in reducing cardiovascular morbidity and mortality. Circulating microRNAs are emerging as potential biomarkers for a number of conditions due to their stability and accessibility. PA is known to alter microRNA expression in adrenocortical tissue; if these changes or their effects are mirrored in the circulating miRNA profile, then this could be exploited by a diagnostic test. However, the reproducibility of studies to identify biomarker-circulating microRNAs has proved difficult for other conditions due to a series of technical challenges. Therefore, any studies seeking to definitively identify circulating microRNA biomarkers of PA must address this in their design. To this end, we are currently conducting the circulating microRNA arm of the ongoing ENS@T-HT study. In this review article, we present evidence to support the utility of circulating microRNAs as PA biomarkers, describe the practical challenges to this approach and, using ENS@T-HT as an example, discuss how these might be overcome.
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inserm-03845206 , version 1 (09-11-2022)

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Scott M Mackenzie, Hannah Saunders, Josie C van Kralingen, Stacy Robertson, Alexandra Riddell, et al.. Circulating microRNAs as Diagnostic Markers in Primary Aldosteronism. Cancers, 2021, 13 (21), pp.5312. ⟨10.3390/cancers13215312⟩. ⟨inserm-03845206⟩
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