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Journal Articles Nephrology Dialysis Transplantation Year : 2022

Ageing meets kidney disease


Chronic kidney disease (CKD) is defined as abnormalities of kidney structure or function, present for longer than 3 months, with implications for health. The most used diagnostic criteria are a urinary albumin: creatinine ratio ≧30 mg/g or an estimated glomerular filtration rate (eGFR) \textless60 ml/min/1.73 m2. Either of these diagnostic thresholds are associated to adverse health outcomes. GFR decreases with age and the prevalence of CKD is highest in older adults; moreover, the presence of CKD is associated with an increased risk of all-cause and cardiovascular death related to accelerated ageing in all age ranges, and the absolute increase in risk is highest for those aged over 75 years. Indeed, premature death is a more common outcome than CKD progression to kidney failure requiring kidney replacement therapy. The progressive ageing of the world population contributes to the projection that CKD will become the second commonest cause of death before the end of the century in countries with long life expectancy. The current collection of selected studies on kidney disease and ageing published in Age&Ageing, NDT, and CKJ provides an overview of key topics, including cognitive decline, sarcopenia, wasting and cardiovascular and non-cardiovascular morbidity and mortality, the management of kidney failure and gender differences in CKD progression.
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inserm-03830416 , version 1 (26-10-2022)



A. Ortiz, F. Mattace-Raso, M. J. Soler, D. Fouque. Ageing meets kidney disease. Nephrology Dialysis Transplantation, 2022, pp.gfac199. ⟨10.1093/ndt/gfac199⟩. ⟨inserm-03830416⟩
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