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Journal Articles Nutrients Year : 2022

Chronic Intestinal Failure in Children: An International Multicenter Cross-Sectional Survey

1 OIRM-S - Regione Piemonte Azienda Ospedaliera - S. Anna [Turin, Italy]
2 OBG - Ospedale Bambin Gesù [Rome, Italy]
3 CRMDR - Centre de Référence des Maladies Digestives Rares [AP-HP Hôpital Robert-Debré]
4 Emma Children’s Hospital
5 Amsterdam UMC - Amsterdam University Medical Center
6 SCMC - Schneider Children’s Medical Center [Petah Tikva, Israel]
7 TAU - Tel Aviv University
8 IRCCS Istituto Giannina Gaslini [Genoa, Italy]
9 University of Naples Federico II = Università degli studi di Napoli Federico II
10 Birmingham Women's and Children's NHS Foundation Trust
11 CarMeN - Cardiovasculaire, métabolisme, diabétologie et nutrition
12 HFME - Hôpital Femme Mère Enfant [CHU - HCL]
13 HUS - Helsinki University Hospital [Finland]
14 Eramus MC-Sophia Children’s Hospital
15 Children’s Hospital Srebrnjak [Zagreb, Croatia]
16 CHQ - Children’s Health Queensland [Brisbane]
17 Royal Children’s Hospital & Department of Paediatrics [Parkville, VIC, Australia]
18 King‘s College London
19 Hosp P Giovanni XXIII - Hospital Papa Giovanni XXIII
20 AOUP - Azienda Ospedale Università di Padova = Hospital-University of Padua
21 CCUH - Children's Clinical University Hospital [Riga, Latvia]
22 Institute for Maternal and Child Health - IRCCS “Burlo Garofolo” [Trieste]
23 LIFT - Leuven Intestinal Failure and Transplantation [Leuven, Belgium]
24 BAPM - Bulgarian Association of Patients with Malnutrition [Sofia, Bulgaria]
25 Sahlgrenska University Hospital [Gothenburg]
26 2O - Ospedale Orlandi [Bussolengo, Italy]
27 Hospital Universitario 12 de Octubre [Madrid]
28 UNIBO - Alma Mater Studiorum Università di Bologna = University of Bologna
29 AOUB - IRCCS Azienda Ospedaliero-Universitaria di Bologna
30 Salford Royal NHS Foundation Trust [Salford, UK]
J. Hind
  • Function : Author

Abstract

BACKGROUND: The European Society for Clinical Nutrition and Metabolism database for chronic intestinal failure (CIF) was analyzed to investigate factors associated with nutritional status and the intravenous supplementation (IVS) dependency in children. METHODS: Data collected: demographics, CIF mechanism, home parenteral nutrition program, z-scores of weight-for-age (WFA), length or height-for-age (LFA/HFA), and body mass index-for-age (BMI-FA). IVS dependency was calculated as the ratio of daily total IVS energy over estimated resting energy expenditure (%IVSE/REE). RESULTS: Five hundred and fifty-eight patients were included, 57.2% of whom were male. CIF mechanisms at age 1-4 and 14-18 years, respectively: SBS 63.3%, 37.9%; dysmotility or mucosal disease: 36.7%, 62.1%. One-third had WFA and/or LFA/HFA z-scores < -2. One-third had %IVSE/REE > 125%. Multivariate analysis showed that mechanism of CIF was associated with WFA and/or LFA/HFA z-scores (negatively with mucosal disease) and %IVSE/REE (higher for dysmotility and lower in SBS with colon in continuity), while z-scores were negatively associated with %IVSE/REE. CONCLUSIONS: The main mechanism of CIF at young age was short bowel syndrome (SBS), whereas most patients facing adulthood had intestinal dysmotility or mucosal disease. One-third were underweight or stunted and had high IVS dependency. Considering that IVS dependency was associated with both CIF mechanisms and nutritional status, IVS dependency is suggested as a potential marker for CIF severity in children.
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Dates and versions

inserm-03755219 , version 1 (22-08-2022)

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A. Lezo, A. Diamanti, E. M. Marinier, M. Tabbers, A. Guz-Mark, et al.. Chronic Intestinal Failure in Children: An International Multicenter Cross-Sectional Survey. Nutrients, 2022, 14 (9), pp.1889. ⟨10.3390/nu14091889⟩. ⟨inserm-03755219⟩
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