Does Endothelial Vulnerability in OSA Syndrome Promote COVID-19 Encephalopathy? - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles Chest Year : 2021

Does Endothelial Vulnerability in OSA Syndrome Promote COVID-19 Encephalopathy?

Abstract

Abstract Study Objectives The COVID-19 pandemic has had dramatic effects on society and people’s daily habits. In this observational study, we recorded objective data on sleep macro- and microarchitecture repeatedly over several nights before and during the COVID-19 government-imposed lockdown. The main objective was to evaluate changes in patterns of sleep duration and architecture during home confinement using the pre-confinement period as a control. Methods Participants were regular users of a sleep-monitoring headband that records, stores, and automatically analyzes physiological data in real time, equivalent to polysomnography. We measured sleep onset duration, total sleep time, duration of sleep stages (N2, N3, and rapid eye movement [REM]), and sleep continuity. Via the user’s smartphone application, participants filled in questionnaires on how lockdown changed working hours, eating behavior, and daily life at home. They also filled in the Insomnia Severity Index, reduced Morningness–Eveningness Questionnaire, and Hospital Anxiety and Depression Scale questionnaires, allowing us to create selected subgroups. Results The 599 participants were mainly men (71%) of median age 47 (interquartile range: 36–59). Compared to before lockdown, during lockdown individuals slept more overall (mean +3·83 min; SD: ±1.3), had less deep sleep (N3), more light sleep (N2), and longer REM sleep (mean +3·74 min; SD: ±0.8). They exhibited less weekend-specific changes, suggesting less sleep restriction during the week. Changes were most pronounced in individuals reporting eveningness preferences, suggesting relative sleep deprivation in this population and exacerbated sensitivity to societal changes. Conclusion This unique dataset should help us understand the effects of lockdown on sleep architecture and on our health.
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Dates and versions

inserm-03388028 , version 1 (20-10-2021)

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Gautier Breville, Dan Adler, Marjolaine Uginet, Frederic Assal, Renaud Tamisier, et al.. Does Endothelial Vulnerability in OSA Syndrome Promote COVID-19 Encephalopathy?. Chest, 2021, 160 (2), pp.e161-e164. ⟨10.1016/j.chest.2021.04.043⟩. ⟨inserm-03388028⟩
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