Acoustic and Elastic Properties of a Blood Clot during Microbubble-Enhanced Sonothrombolysis: Hardening of the Clot with Inertial Cavitation - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles Pharmaceutics Year : 2021

Acoustic and Elastic Properties of a Blood Clot during Microbubble-Enhanced Sonothrombolysis: Hardening of the Clot with Inertial Cavitation

Laurent Auboire
Damien Fouan
  • Function : Author
  • PersonId : 1111333
Jean-Marc Grégoire
Fréderic Ossant
  • Function : Author
  • PersonId : 977517
  • IdRef : 148633196
Camille Plag
  • Function : Author
  • PersonId : 1111334
Ayache Bouakaz

Abstract

Stroke is the second leading cause of death worldwide. Existing therapies present limitations, and other therapeutic alternatives are sought, such as sonothrombolysis with microbubbles (STL). The aim of this study was to evaluate the change induced by STL with or without recombinant tissue-type plasminogen activator (rtPA) on the acoustic and elastic properties of the blood clot by measuring its sound speed (SoS) and shear wave speed (SWS) with high frequency ultrasound and ultrafast imaging, respectively. An in-vitro setup was used and human blood clots were submitted to a combination of microbubbles and rtPA. The results demonstrate that STL induces a raise of SoS in the blood clot, specifically when combined with rtPA (p < 0.05). Moreover, the combination of rtPA and STL induces a hardening of the clot in comparison to rtPA alone (p < 0.05). This is the first assessment of acoustoelastic properties of blood clots during STL. The combination of rtPA and STL induce SoS and hardening of the clot, which is known to impair the penetration of thrombolytic drugs and their efficacy

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Bioengineering
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Dates and versions

inserm-03354808 , version 1 (26-09-2021)

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Laurent Auboire, Damien Fouan, Jean-Marc Grégoire, Fréderic Ossant, Camille Plag, et al.. Acoustic and Elastic Properties of a Blood Clot during Microbubble-Enhanced Sonothrombolysis: Hardening of the Clot with Inertial Cavitation. Pharmaceutics, 2021, 13, pp.1566. ⟨10.3390/pharmaceutics13101566⟩. ⟨inserm-03354808⟩
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