[Mutltifaceted biological roles of leptin] - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles Annales de Biologie Clinique Year : 2020

[Mutltifaceted biological roles of leptin]

Diane Dufour-Rainfray

Abstract

The identification of leptin allowed the discovery of a new endocrine system. This major adipokine controlling energy homeostasis is also involved in the regulation of neuroendocrine function and fertility. Unfortunately, leptin is not able to treat common obesity, which associates hyperleptinemia and resistance to the hormone. Conversely, treatment with recombinant leptin is effective in situations of leptin deficiency. Several pathophysiological situations associated with adipose tissue dysfunctions and abnormal regulation of leptin secretion are discussed in this review. The advantage of the potential use of the leptin assay in some pathophysiological conditions is proposed.
Fichier principal
Vignette du fichier
abc-317168-45612.pdf (308.79 Ko) Télécharger le fichier
Origin : Publication funded by an institution

Dates and versions

inserm-03226392 , version 1 (14-05-2021)

Identifiers

Cite

R. Charchour, Diane Dufour-Rainfray, G. Morineau, C. Vatier, S. Fellahi, et al.. [Mutltifaceted biological roles of leptin]. Annales de Biologie Clinique, 2020, 78 (3), pp.231--242. ⟨10.1684/abc.2020.1560⟩. ⟨inserm-03226392⟩
117 View
250 Download

Altmetric

Share

Gmail Facebook X LinkedIn More