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Journal Articles Annales de Biologie Clinique Year : 2020

[Mutltifaceted biological roles of leptin]

Diane Dufour-Rainfray


The identification of leptin allowed the discovery of a new endocrine system. This major adipokine controlling energy homeostasis is also involved in the regulation of neuroendocrine function and fertility. Unfortunately, leptin is not able to treat common obesity, which associates hyperleptinemia and resistance to the hormone. Conversely, treatment with recombinant leptin is effective in situations of leptin deficiency. Several pathophysiological situations associated with adipose tissue dysfunctions and abnormal regulation of leptin secretion are discussed in this review. The advantage of the potential use of the leptin assay in some pathophysiological conditions is proposed.
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inserm-03226392 , version 1 (14-05-2021)



R. Charchour, Diane Dufour-Rainfray, G. Morineau, C. Vatier, S. Fellahi, et al.. [Mutltifaceted biological roles of leptin]. Annales de Biologie Clinique, 2020, 78 (3), pp.231--242. ⟨10.1684/abc.2020.1560⟩. ⟨inserm-03226392⟩
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