MAIT Cells in Type 1 Diabetes Mouse Models - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Book Sections Year : 2020

MAIT Cells in Type 1 Diabetes Mouse Models


MAIT cells are unconventional T cells expressing a semi-invariant αβ TCR, and they recognize bacterial metabolites via the highly conserved MR1 protein. MAIT cells interact with gut microbiota and literature reports alterations of gut homeostasis in type 1 diabetes (T1D), suggesting the involvement of MAIT cells in T1D. Since NOD mice is a well-established mouse model of T1D, MAIT cells were studied in these mice to evaluate their potential involvement in disease development. This chapter describes the material and methods required to characterize MAIT cells and to determine their function in T1D mouse models.


No file

Dates and versions

inserm-03035922 , version 1 (02-12-2020)



Isabelle Nel, Lucie Beaudoin, Agnès Lehuen. MAIT Cells in Type 1 Diabetes Mouse Models. MAIT Cells, 2098, pp.283-297, 2020, ⟨10.1007/978-1-0716-0207-2_18⟩. ⟨inserm-03035922⟩
21 View
0 Download



Gmail Mastodon Facebook X LinkedIn More