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Journal Articles European Respiratory Review Year : 2020

Early origins of lung disease: Towards an interdisciplinary approach


The prenataland perinatal environment can have profound effects on development of chronic inflammatory diseases. However, mechanistic insight into how the early life microenvironment can impact upon development of the lung and immune system, and consequent initiation and progression of respiratory diseases is still emerging. Recent studies investigating the developmental origins of lung diseases have started to delineate the effects of early life changes in the lung, environmental exposures and immune maturation on development of childhood and adult lung diseases. While the influencing factors have been described and studied in mostly animal models, it remains challenging to pinpoint exactly which factors and at which time pointare detrimental in lung development leading to respiratory disease later in life. To advance our understanding of early origins of chronic lung disease and to allow for proper dissemination and application of this knowledge, we propose four major focus areas: 1) policy and education, 2) clinical assessment, 3) basic and translational research, and 4) infrastructure and tools, and discuss future directions for advancement. This review is a follow-up of the discussions at the ERS Research Seminar “Early origins of lung disease: Towards an interdisciplinary approach” (Lisbon, November 922019).
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inserm-02920087 , version 1 (24-08-2020)


  • HAL Id : inserm-02920087 , version 1


Niki D J Ubags, Miguel A Alejandre Alcazar, Suhas G Kallapur, Sylvia Knapp, Sophie Lanone, et al.. Early origins of lung disease: Towards an interdisciplinary approach: Early origins of lung disease. European Respiratory Review, In press, Epub 2020 Sep. ⟨inserm-02920087⟩
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