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Journal Articles Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring Year : 2019

Progress update from the hippocampal subfields group

1 RRI - Rotman Research Institute at the Baycrest Centre
2 University of Toronto
3 SJSU - San Jose State University [San Jose]
4 Wayne State University [Detroit]
5 Memory and Aging Center [San Francisco, CA, États-Unis]
6 Douglas Mental Health University Institute [Montréal]
7 INM-1 - Institute of Neuroscience and Medicine [Jülich]
8 Massachusetts General Hospital [Boston]
9 Johns Hopkins University School of Medicine [Baltimore]
10 Skane University Hospital [Lund]
11 DZNE - German Research Center for Neurodegenerative Diseases - Deutsches Zentrum für Neurodegenerative Erkrankungen
12 LENITEM - Neuroimaging and Telemedicine
13 DRC - Dementia Research Centre [London]
14 University of Oregon [Eugene]
15 McGill University = Université McGill [Montréal, Canada]
16 PhIND - Physiopathologie et imagerie des troubles neurologiques
17 Cyceron - GIP Cyceron
18 UNICAEN - Université de Caen Normandie
19 UWO - University of Western Ontario
20 Allen Institute for Brain Science [Seattle, WA, USA]
21 University Medical Center [Utrecht]
22 University of Alberta
23 School of Medicine - CRIB - Human Neuroanatomy Laboratory [Albacete, Spain]
24 UC - University of California
25 University of Michigan Medical School [Ann Arbor]
26 Heinrich Heine Universität Düsseldorf = Heinrich Heine University [Düsseldorf]
27 UT Dallas - University of Texas at Dallas [Richardson]
28 Max Planck Institute for Human Development
29 UC Davis - University of California [Davis]
30 Freie Universität Berlin
31 UC San Francisco - University of California [San Francisco]
32 FSU - Florida State University [Tallahassee]
33 Weizmann Institutes of Science [Rehovot, Israel]
34 UBC - University of British Columbia
35 University of Pennsylvania
36 Goethe-University Frankfurt am Main
37 UC Irvine - University of California [Irvine]
38 UCLA - University of California [Los Angeles]
39 Northwestern University Feinberg School of Medicine
40 PICSL - Penn Image Computing & Science Lab [Philadelphia]
Marina Boccardi


Introduction: Heterogeneity of segmentation protocols for medial temporal lobe regions and hippo-campal subfields on in vivo magnetic resonance imaging hinders the ability to integrate findings across studies. We aim to develop a harmonized protocol based on expert consensus and histological evidence. Methods: Our international working group, funded by the EU Joint Programme-Neurodegenerative Disease Research (JPND), is working toward the production of a reliable, validated, harmonized protocol for segmentation of medial temporal lobe regions. The working group uses a novel postmortem data set and online consensus procedures to ensure validity and facilitate adoption. Results: This progress report describes the initial results and milestones that we have achieved to date, including the development of a draft protocol and results from the initial reliability tests and consensus procedures. Discussion: A harmonized protocol will enable the standardization of segmentation methods across laboratories interested in medial temporal lobe research worldwide.
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Dates and versions

inserm-02747115 , version 1 (03-06-2020)



Rosanna K Olsen, Valerie A Carr, Ana M Daugherty, Renaud La Joie, Robert S.C. Amaral, et al.. Progress update from the hippocampal subfields group. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 2019, 11 (1), pp.439-449. ⟨10.1016/j.dadm.2019.04.001⟩. ⟨inserm-02747115⟩
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