Host-Range shift between emerging P[8]-4 Rotavirus and Common P[8] and P[4] Strains - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles Journal of Infectious Diseases and Therapy Year : 2020

Host-Range shift between emerging P[8]-4 Rotavirus and Common P[8] and P[4] Strains

Abstract

In Tunisia, we observed that rotavirus P[8]-3 and P[4] in young children with gastroenteritis associate with the secretor histo-blood-group phenotype. Inversely, the emerging P[8]-4, representing 10% of cases, was exclusively found among nonsecretor patients. Unlike VP8* from P[8]-3 and P[4] strains, the P[8]-4 VP8* protein attached to glycans from saliva samples regardless of the donors Secretor status. Interestingly, a high frequency of FUT2 enzyme deficiency (nonsecretor phenotype) was observed in the population. This may allow co-circulation of P[8]-3 and P[8]-4 strains in secretor and nonsecretor children, respectively.
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Dates and versions

inserm-02541930 , version 1 (14-04-2020)

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Amira Khachou, Béatrice Le Moullac-Vaidye, Cécile Peltier, Adrien Breiman, Marie Imbert-Marcille, et al.. Host-Range shift between emerging P[8]-4 Rotavirus and Common P[8] and P[4] Strains: Host-range shift of P[8] rotaviruses. Journal of Infectious Diseases and Therapy, 2020, pp.jiaa122. ⟨10.1093/infdis/jiaa122⟩. ⟨inserm-02541930⟩
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